Cargando…
Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients
BACKGROUND: The risk of recurrent stroke following a minor stroke or transient ischemic attack (TIA) is high, when inflammation might play an important role. We aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) in predicting composite cardiovascular events in patients with minor st...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093519/ https://www.ncbi.nlm.nih.gov/pubmed/33958997 http://dx.doi.org/10.3389/fnagi.2021.646961 |
_version_ | 1783687824675962880 |
---|---|
author | Chan, Ka Lung Feng, Xueyan Ip, Bonaventure Huang, Shangmeng Ma, Sze Ho Fan, Florence S. Y. Ip, Hing Lung Huang, Li’an Mok, Vincent C. T. Soo, Yannie O. Y. Leung, Thomas W. Leng, Xinyi |
author_facet | Chan, Ka Lung Feng, Xueyan Ip, Bonaventure Huang, Shangmeng Ma, Sze Ho Fan, Florence S. Y. Ip, Hing Lung Huang, Li’an Mok, Vincent C. T. Soo, Yannie O. Y. Leung, Thomas W. Leng, Xinyi |
author_sort | Chan, Ka Lung |
collection | PubMed |
description | BACKGROUND: The risk of recurrent stroke following a minor stroke or transient ischemic attack (TIA) is high, when inflammation might play an important role. We aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) in predicting composite cardiovascular events in patients with minor stroke and TIA. METHODS: Consecutive patients with acute minor stroke or TIA admitted within 24 h of symptoms onset during a 5-year period in a prospective stroke registry were analyzed. We calculated the NLR dividing absolute neutrophil count by absolute lymphocyte count tested within 24 h of admission. NLR ≥4th quartile was defined as high NLR. A composite outcome was defined as stroke, acute coronary syndrome or vascular death within 1 year. We investigated associations between NLR and the composite outcome in univariate and multivariate analyses, among all patients and in those aged over 60 years (i.e., older patients). RESULTS: Overall, 841 patients (median age 68 years; 60.4% males) were recruited. No significant independent association was found between NLR and the composite outcome in multivariate analysis in the overall cohort. Among the 612 older patients (median age 73 years; 59.2% males), the median NLR was 2.76 (interquartile range 1.96−4.00) and 148 (24.2%) patients had high NLR. The composite outcome occurred in 77 (12.6%) older patients, who were more likely to have a high NLR (39.0% versus 22.1%; p = 0.001) than those without a composite outcome. In multivariate logistic regression, high NLR (adjusted odds ratio 2.00; 95% confidence interval 1.07−3.75; p = 0.031) was independently associated with the composite outcome in older patients. CONCLUSION: In older (aged ≥60 years) patients with acute minor stroke or TIA, a higher NLR, a marker of systemic inflammation that can be easily obtained in routine blood tests, is an independent predictor of subsequent cardiovascular events. |
format | Online Article Text |
id | pubmed-8093519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80935192021-05-05 Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients Chan, Ka Lung Feng, Xueyan Ip, Bonaventure Huang, Shangmeng Ma, Sze Ho Fan, Florence S. Y. Ip, Hing Lung Huang, Li’an Mok, Vincent C. T. Soo, Yannie O. Y. Leung, Thomas W. Leng, Xinyi Front Aging Neurosci Neuroscience BACKGROUND: The risk of recurrent stroke following a minor stroke or transient ischemic attack (TIA) is high, when inflammation might play an important role. We aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) in predicting composite cardiovascular events in patients with minor stroke and TIA. METHODS: Consecutive patients with acute minor stroke or TIA admitted within 24 h of symptoms onset during a 5-year period in a prospective stroke registry were analyzed. We calculated the NLR dividing absolute neutrophil count by absolute lymphocyte count tested within 24 h of admission. NLR ≥4th quartile was defined as high NLR. A composite outcome was defined as stroke, acute coronary syndrome or vascular death within 1 year. We investigated associations between NLR and the composite outcome in univariate and multivariate analyses, among all patients and in those aged over 60 years (i.e., older patients). RESULTS: Overall, 841 patients (median age 68 years; 60.4% males) were recruited. No significant independent association was found between NLR and the composite outcome in multivariate analysis in the overall cohort. Among the 612 older patients (median age 73 years; 59.2% males), the median NLR was 2.76 (interquartile range 1.96−4.00) and 148 (24.2%) patients had high NLR. The composite outcome occurred in 77 (12.6%) older patients, who were more likely to have a high NLR (39.0% versus 22.1%; p = 0.001) than those without a composite outcome. In multivariate logistic regression, high NLR (adjusted odds ratio 2.00; 95% confidence interval 1.07−3.75; p = 0.031) was independently associated with the composite outcome in older patients. CONCLUSION: In older (aged ≥60 years) patients with acute minor stroke or TIA, a higher NLR, a marker of systemic inflammation that can be easily obtained in routine blood tests, is an independent predictor of subsequent cardiovascular events. Frontiers Media S.A. 2021-04-20 /pmc/articles/PMC8093519/ /pubmed/33958997 http://dx.doi.org/10.3389/fnagi.2021.646961 Text en Copyright © 2021 Chan, Feng, Ip, Huang, Ma, Fan, Ip, Huang, Mok, Soo, Leung and Leng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Chan, Ka Lung Feng, Xueyan Ip, Bonaventure Huang, Shangmeng Ma, Sze Ho Fan, Florence S. Y. Ip, Hing Lung Huang, Li’an Mok, Vincent C. T. Soo, Yannie O. Y. Leung, Thomas W. Leng, Xinyi Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients |
title | Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients |
title_full | Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients |
title_fullStr | Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients |
title_full_unstemmed | Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients |
title_short | Elevated Neutrophil to Lymphocyte Ratio Associated With Increased Risk of Recurrent Vascular Events in Older Minor Stroke or TIA Patients |
title_sort | elevated neutrophil to lymphocyte ratio associated with increased risk of recurrent vascular events in older minor stroke or tia patients |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093519/ https://www.ncbi.nlm.nih.gov/pubmed/33958997 http://dx.doi.org/10.3389/fnagi.2021.646961 |
work_keys_str_mv | AT chankalung elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT fengxueyan elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT ipbonaventure elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT huangshangmeng elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT maszeho elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT fanflorencesy elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT iphinglung elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT huanglian elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT mokvincentct elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT sooyannieoy elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT leungthomasw elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients AT lengxinyi elevatedneutrophiltolymphocyteratioassociatedwithincreasedriskofrecurrentvasculareventsinolderminorstrokeortiapatients |