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Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a heterogeneous disease that is characterized by abnormalities in social communication and interaction as well as repetitive behaviors and restricted interests. Structural brain imaging has identified significant cortical folding alterations in ASD; however, relativ...

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Autores principales: Ning, Mingmin, Li, Cuicui, Gao, Lei, Fan, Jingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093770/
https://www.ncbi.nlm.nih.gov/pubmed/33959045
http://dx.doi.org/10.3389/fpsyt.2021.619367
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author Ning, Mingmin
Li, Cuicui
Gao, Lei
Fan, Jingyi
author_facet Ning, Mingmin
Li, Cuicui
Gao, Lei
Fan, Jingyi
author_sort Ning, Mingmin
collection PubMed
description Autism spectrum disorder (ASD) is a heterogeneous disease that is characterized by abnormalities in social communication and interaction as well as repetitive behaviors and restricted interests. Structural brain imaging has identified significant cortical folding alterations in ASD; however, relatively less known is whether the core symptoms are related to neuroanatomical differences. In this study, we aimed to explore core-symptom-anchored gyrification alterations and their developmental trajectories in ASD. We measured the cortical vertex-wise gyrification index (GI) in 321 patients with ASD (aged 7–39 years) and 350 typically developing (TD) subjects (aged 6–33 years) across 8 sites from the Autism Brain Imaging Data Exchange I (ABIDE I) repository and a longitudinal sample (14 ASD and 7 TD, aged 9–14 years in baseline and 12–18 years in follow-up) from ABIDE II. Compared with TD, the general ASD patients exhibited a mixed pattern of both hypo- and hyper- and different developmental trajectories of gyrification. By parsing the ASD patients into three subgroups based on the subscores of the Autism Diagnostic Interview—Revised (ADI-R) scale, we identified core-symptom-specific alterations in the reciprocal social interaction (RSI), communication abnormalities (CA), and restricted, repetitive, and stereotyped patterns of behavior (RRSB) subgroups. We also showed atypical gyrification patterns and developmental trajectories in the subgroups. Furthermore, we conducted a meta-analysis to locate the core-symptom-anchored brain regions (circuits). In summary, the current study shows that ASD is associated with abnormal cortical folding patterns. Core-symptom-based classification can find more subtle changes in gyrification. These results suggest that cortical folding pattern encodes changes in symptom dimensions, which promotes the understanding of neuroanatomical basis, and clinical utility in ASD.
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spelling pubmed-80937702021-05-05 Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder Ning, Mingmin Li, Cuicui Gao, Lei Fan, Jingyi Front Psychiatry Psychiatry Autism spectrum disorder (ASD) is a heterogeneous disease that is characterized by abnormalities in social communication and interaction as well as repetitive behaviors and restricted interests. Structural brain imaging has identified significant cortical folding alterations in ASD; however, relatively less known is whether the core symptoms are related to neuroanatomical differences. In this study, we aimed to explore core-symptom-anchored gyrification alterations and their developmental trajectories in ASD. We measured the cortical vertex-wise gyrification index (GI) in 321 patients with ASD (aged 7–39 years) and 350 typically developing (TD) subjects (aged 6–33 years) across 8 sites from the Autism Brain Imaging Data Exchange I (ABIDE I) repository and a longitudinal sample (14 ASD and 7 TD, aged 9–14 years in baseline and 12–18 years in follow-up) from ABIDE II. Compared with TD, the general ASD patients exhibited a mixed pattern of both hypo- and hyper- and different developmental trajectories of gyrification. By parsing the ASD patients into three subgroups based on the subscores of the Autism Diagnostic Interview—Revised (ADI-R) scale, we identified core-symptom-specific alterations in the reciprocal social interaction (RSI), communication abnormalities (CA), and restricted, repetitive, and stereotyped patterns of behavior (RRSB) subgroups. We also showed atypical gyrification patterns and developmental trajectories in the subgroups. Furthermore, we conducted a meta-analysis to locate the core-symptom-anchored brain regions (circuits). In summary, the current study shows that ASD is associated with abnormal cortical folding patterns. Core-symptom-based classification can find more subtle changes in gyrification. These results suggest that cortical folding pattern encodes changes in symptom dimensions, which promotes the understanding of neuroanatomical basis, and clinical utility in ASD. Frontiers Media S.A. 2021-04-20 /pmc/articles/PMC8093770/ /pubmed/33959045 http://dx.doi.org/10.3389/fpsyt.2021.619367 Text en Copyright © 2021 Ning, Li, Gao and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ning, Mingmin
Li, Cuicui
Gao, Lei
Fan, Jingyi
Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder
title Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder
title_full Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder
title_fullStr Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder
title_full_unstemmed Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder
title_short Core-Symptom-Defined Cortical Gyrification Differences in Autism Spectrum Disorder
title_sort core-symptom-defined cortical gyrification differences in autism spectrum disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093770/
https://www.ncbi.nlm.nih.gov/pubmed/33959045
http://dx.doi.org/10.3389/fpsyt.2021.619367
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