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CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance

OBJECTIVE: Arcuate nucleus neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons drive ingestive behavior. The M-current, a subthreshold non-inactivating potassium current, plays a critical role in regulating NPY/AgRP neuronal excitability. Fasting decreases while 17β-estradiol increases the M-cu...

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Detalles Bibliográficos
Autores principales:	Stincic, Todd L., Bosch, Martha A., Hunker, Avery C., Juarez, Barbara, Connors, Ashley M., Zweifel, Larry S., Rønnekleiv, Oline K., Kelly, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093934/ https://www.ncbi.nlm.nih.gov/pubmed/33766732 http://dx.doi.org/10.1016/j.molmet.2021.101218

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