Mitochondrial dysfunction induced by callyspongiolide promotes autophagy-dependent cell death

Callyspongiolide is a marine macrolide known to induce caspase-independent cancer cell death. While its toxic effects have been known, the mechanism leading to cell death is yet to be identified. We report that Callyspongiolide R form at C-21 (cally2R) causes mitochondrial dysfunction by inhibiting...

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Detalles Bibliográficos
Autores principales: Lee, Soohyun, Jeong, Yoonjeong, Roe, Jae-Seok, Huh, Hoyoung, Paik, Sang Hoon, Song, Jaewhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093938/
https://www.ncbi.nlm.nih.gov/pubmed/33792534
http://dx.doi.org/10.5483/BMBRep.2021.54.4.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093938/
https://www.ncbi.nlm.nih.gov/pubmed/33792534
http://dx.doi.org/10.5483/BMBRep.2021.54.4.037

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