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CD1d deficiency limits tolerogenic properties of peritoneal macrophages
Invariant natural killer T (iNKT) cells are involved in various autoimmune diseases. Although iNKT cells are arthritogenic, transforming growth factor beta (TGFβ)-treated tolerogenic peritoneal macrophages (Tol-pMφ) from wild-type (WT) mice are more tolerogenic than those from CD1d knock-out iNKT ce...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093942/ https://www.ncbi.nlm.nih.gov/pubmed/33407995 http://dx.doi.org/10.5483/BMBRep.2021.54.4.183 |
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author | Basri, Fathihah Jung, Sundo Park, Se Hoon Park, Se-Ho |
author_facet | Basri, Fathihah Jung, Sundo Park, Se Hoon Park, Se-Ho |
author_sort | Basri, Fathihah |
collection | PubMed |
description | Invariant natural killer T (iNKT) cells are involved in various autoimmune diseases. Although iNKT cells are arthritogenic, transforming growth factor beta (TGFβ)-treated tolerogenic peritoneal macrophages (Tol-pMφ) from wild-type (WT) mice are more tolerogenic than those from CD1d knock-out iNKT cell-deficient mice in a collagen-induced arthritis (CIA) model. The underlying mechanism by which pMφ can act as tolerogenic antigen presenting cells (APCs) is currently unclear. To determine cellular mechanisms underlying CD1d-dependent tolerogenicity of pMφ, in vitro and in vivo characteristics of pMφ were investigated. Unlike dendritic cells or splenic Mφ, pMφ from CD1d(+/−) mice showed lower expression levels of costimulatory molecule CD86 and produced lower amounts of inflammatory cytokines upon lipopolysaccharide (LPS) stimulation compared to pMφ from CD1d-deficient mice. In a CIA model of CD1d-deficient mice, adoptively transferred pMφ from WT mice reduced the severity of arthritis. However, pMφ from CD1d-deficient mice were unable to reduce the severity of arthritis. Hence, the tolerogenicity of pMφ is a cell-intrinsic property that is probably confer-red by iNKT cells during pMφ development rather than by interactions of pMφ with iNKT cells during antigen presentation to cognate T cells. |
format | Online Article Text |
id | pubmed-8093942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-80939422021-05-13 CD1d deficiency limits tolerogenic properties of peritoneal macrophages Basri, Fathihah Jung, Sundo Park, Se Hoon Park, Se-Ho BMB Rep Article Invariant natural killer T (iNKT) cells are involved in various autoimmune diseases. Although iNKT cells are arthritogenic, transforming growth factor beta (TGFβ)-treated tolerogenic peritoneal macrophages (Tol-pMφ) from wild-type (WT) mice are more tolerogenic than those from CD1d knock-out iNKT cell-deficient mice in a collagen-induced arthritis (CIA) model. The underlying mechanism by which pMφ can act as tolerogenic antigen presenting cells (APCs) is currently unclear. To determine cellular mechanisms underlying CD1d-dependent tolerogenicity of pMφ, in vitro and in vivo characteristics of pMφ were investigated. Unlike dendritic cells or splenic Mφ, pMφ from CD1d(+/−) mice showed lower expression levels of costimulatory molecule CD86 and produced lower amounts of inflammatory cytokines upon lipopolysaccharide (LPS) stimulation compared to pMφ from CD1d-deficient mice. In a CIA model of CD1d-deficient mice, adoptively transferred pMφ from WT mice reduced the severity of arthritis. However, pMφ from CD1d-deficient mice were unable to reduce the severity of arthritis. Hence, the tolerogenicity of pMφ is a cell-intrinsic property that is probably confer-red by iNKT cells during pMφ development rather than by interactions of pMφ with iNKT cells during antigen presentation to cognate T cells. Korean Society for Biochemistry and Molecular Biology 2021-04-30 2021-04-30 /pmc/articles/PMC8093942/ /pubmed/33407995 http://dx.doi.org/10.5483/BMBRep.2021.54.4.183 Text en Copyright © 2021 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Basri, Fathihah Jung, Sundo Park, Se Hoon Park, Se-Ho CD1d deficiency limits tolerogenic properties of peritoneal macrophages |
title | CD1d deficiency limits tolerogenic properties of peritoneal macrophages |
title_full | CD1d deficiency limits tolerogenic properties of peritoneal macrophages |
title_fullStr | CD1d deficiency limits tolerogenic properties of peritoneal macrophages |
title_full_unstemmed | CD1d deficiency limits tolerogenic properties of peritoneal macrophages |
title_short | CD1d deficiency limits tolerogenic properties of peritoneal macrophages |
title_sort | cd1d deficiency limits tolerogenic properties of peritoneal macrophages |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093942/ https://www.ncbi.nlm.nih.gov/pubmed/33407995 http://dx.doi.org/10.5483/BMBRep.2021.54.4.183 |
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