The role of 14‐3‐3 proteins in cell signalling pathways and virus infection

14‐3‐3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14‐3‐3–binding motifs. Recent studies have shown that 14‐3‐3 proteins can also play a role in viral infections. This r...

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Detalles Bibliográficos
Autores principales: Liu, Jiaqi, Cao, Shengliang, Ding, Guofei, Wang, Bin, Li, Yingchao, Zhao, Yuzhong, Shao, Qingyuan, Feng, Jian, Liu, Sidang, Qin, Liting, Xiao, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093981/
https://www.ncbi.nlm.nih.gov/pubmed/33793048
http://dx.doi.org/10.1111/jcmm.16490
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author Liu, Jiaqi
Cao, Shengliang
Ding, Guofei
Wang, Bin
Li, Yingchao
Zhao, Yuzhong
Shao, Qingyuan
Feng, Jian
Liu, Sidang
Qin, Liting
Xiao, Yihong
author_facet Liu, Jiaqi
Cao, Shengliang
Ding, Guofei
Wang, Bin
Li, Yingchao
Zhao, Yuzhong
Shao, Qingyuan
Feng, Jian
Liu, Sidang
Qin, Liting
Xiao, Yihong
author_sort Liu, Jiaqi
collection PubMed
description 14‐3‐3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14‐3‐3–binding motifs. Recent studies have shown that 14‐3‐3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14‐3‐3 proteins in protein trafficking, cell‐cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14‐3‐3 proteins in viral infection and innate immunity are also reviewed.
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spelling pubmed-80939812021-05-10 The role of 14‐3‐3 proteins in cell signalling pathways and virus infection Liu, Jiaqi Cao, Shengliang Ding, Guofei Wang, Bin Li, Yingchao Zhao, Yuzhong Shao, Qingyuan Feng, Jian Liu, Sidang Qin, Liting Xiao, Yihong J Cell Mol Med Reviews 14‐3‐3 proteins are highly conserved in species ranging from yeast to mammals and regulate numerous signalling pathways via direct interactions with proteins carrying phosphorylated 14‐3‐3–binding motifs. Recent studies have shown that 14‐3‐3 proteins can also play a role in viral infections. This review summarizes the biological functions of 14‐3‐3 proteins in protein trafficking, cell‐cycle control, apoptosis, autophagy and other cell signal transduction pathways, as well as the associated mechanisms. Recent findings regarding the role of 14‐3‐3 proteins in viral infection and innate immunity are also reviewed. John Wiley and Sons Inc. 2021-04-01 2021-05 /pmc/articles/PMC8093981/ /pubmed/33793048 http://dx.doi.org/10.1111/jcmm.16490 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Liu, Jiaqi
Cao, Shengliang
Ding, Guofei
Wang, Bin
Li, Yingchao
Zhao, Yuzhong
Shao, Qingyuan
Feng, Jian
Liu, Sidang
Qin, Liting
Xiao, Yihong
The role of 14‐3‐3 proteins in cell signalling pathways and virus infection
title The role of 14‐3‐3 proteins in cell signalling pathways and virus infection
title_full The role of 14‐3‐3 proteins in cell signalling pathways and virus infection
title_fullStr The role of 14‐3‐3 proteins in cell signalling pathways and virus infection
title_full_unstemmed The role of 14‐3‐3 proteins in cell signalling pathways and virus infection
title_short The role of 14‐3‐3 proteins in cell signalling pathways and virus infection
title_sort role of 14‐3‐3 proteins in cell signalling pathways and virus infection
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8093981/
https://www.ncbi.nlm.nih.gov/pubmed/33793048
http://dx.doi.org/10.1111/jcmm.16490
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