Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T-cell responses in a murine acute myeloid leukemia model

We have developed a personalized vaccine in which patientderived leukemia cells are fused to autologous dendritic cells, evoking a polyclonal T-cell response against shared antigens and neoantigens. We postulated that the dendritic cell/acute myeloid leukemia fusion vaccine would demonstrate synergy...

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Detalles Bibliográficos
Autores principales: Stroopinsky, Dina, Liegel, Jessica, Bhasin, Manoj, Cheloni, Giulia, Thomas, Beena, Bhasin, Swati, Panchal, Ruchit, Ghiasuddin, Haider, Rahimian, Maryam, Nahas, Myrna, Orr, Shira, Capelletti, Marzia, Torres, Daniela, Tacettin, Cansu, Weinstock, Matthew, Bisharat, Lina, Morin, Adam, Mahoney, Kathleen M., Ebert, Benjamin, Stone, Richard, Kufe, Donald, Freeman, Gordon J., Rosenblatt, Jacalyn, Avigan, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094093/
https://www.ncbi.nlm.nih.gov/pubmed/33538148
http://dx.doi.org/10.3324/haematol.2020.259457

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