The AD tau core spontaneously self-assembles and recruits full-length tau to filaments

Tau accumulation is a major pathological hallmark of Alzheimer’s disease (AD) and other tauopathies, but the mechanism(s) of tau aggregation remains unclear. Taking advantage of the identification of tau filament cores by cryoelectron microscopy, we demonstrate that the AD tau core possesses the int...

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Detalles Bibliográficos
Autores principales: Carlomagno, Yari, Manne, Sireesha, DeTure, Michael, Prudencio, Mercedes, Zhang, Yong-Jie, Al-Shaikh, Rana Hanna, Dunmore, Judith A., Daughrity, Lillian M., Song, Yuping, Castanedes-Casey, Monica, Lewis-Tuffin, Laura J., Nicholson, Katharine A., Wszolek, Zbigniew K., Dickson, Dennis W., Fitzpatrick, Anthony W.P., Petrucelli, Leonard, Cook, Casey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094113/
https://www.ncbi.nlm.nih.gov/pubmed/33730588
http://dx.doi.org/10.1016/j.celrep.2021.108843

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