Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases

Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) displays unique cutaneous and pathologic features. We describe two cases of myositis-associated rapidly progressive interstitial lung disease (RP-ILD). The patients were two women from Kerala, India. Both pat...

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Autores principales: Mehta, Asmita A, Paul, Tisa, CB, Mithun, Haridas, Nithya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094376/
https://www.ncbi.nlm.nih.gov/pubmed/33910791
http://dx.doi.org/10.1136/bcr-2020-240046
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author Mehta, Asmita A
Paul, Tisa
CB, Mithun
Haridas, Nithya
author_facet Mehta, Asmita A
Paul, Tisa
CB, Mithun
Haridas, Nithya
author_sort Mehta, Asmita A
collection PubMed
description Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) displays unique cutaneous and pathologic features. We describe two cases of myositis-associated rapidly progressive interstitial lung disease (RP-ILD). The patients were two women from Kerala, India. Both patients had anti-MDA5 antibody-positive myositis. Both patients presented with RP-ILD without any clinical features of myositis and succumbed to their illness despite aggressive medical treatment. Anti-MDA5-antibody-positive DM is characterised by amyopathic disease with rapidly progressive and fatal ILD.
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spelling pubmed-80943762021-05-18 Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases Mehta, Asmita A Paul, Tisa CB, Mithun Haridas, Nithya BMJ Case Rep Case Report Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) displays unique cutaneous and pathologic features. We describe two cases of myositis-associated rapidly progressive interstitial lung disease (RP-ILD). The patients were two women from Kerala, India. Both patients had anti-MDA5 antibody-positive myositis. Both patients presented with RP-ILD without any clinical features of myositis and succumbed to their illness despite aggressive medical treatment. Anti-MDA5-antibody-positive DM is characterised by amyopathic disease with rapidly progressive and fatal ILD. BMJ Publishing Group 2021-04-28 /pmc/articles/PMC8094376/ /pubmed/33910791 http://dx.doi.org/10.1136/bcr-2020-240046 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Mehta, Asmita A
Paul, Tisa
CB, Mithun
Haridas, Nithya
Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
title Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
title_full Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
title_fullStr Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
title_full_unstemmed Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
title_short Anti-MDA5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
title_sort anti-mda5 antibody-positive dermatomyositis with rapidly progressive interstitial lung disease: report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094376/
https://www.ncbi.nlm.nih.gov/pubmed/33910791
http://dx.doi.org/10.1136/bcr-2020-240046
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