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Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations

BACKGROUND: Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a natural antagonist of the CXC chemokine receptor 4 (CXCR4). EPI-X4 is a 16-mer peptide that is released from human serum albumin (HSA) by acidic aspartic proteases such as Cathepsin D and E. Since human serum albumin (HSA) is an importa...

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Detalles Bibliográficos
Autores principales:	Gilg, Andrea, Harms, Mirja, Olari, Lia-Raluca, Urbanowitz, Ann-Kathrin, Bonig, Halvard, Münch, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094565/ https://www.ncbi.nlm.nih.gov/pubmed/33941197 http://dx.doi.org/10.1186/s12967-021-02859-6

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