Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6

Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affected in cancer cells and whether Pals1 is implicat...

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Detalles Bibliográficos
Autores principales: Lüttgenau, Simona Mareike, Emming, Christin, Wagner, Thomas, Harms, Julia, Guske, Justine, Weber, Katrin, Neugebauer, Ute, Schröter, Rita, Panichkina, Olga, Pethő, Zoltán, Weber, Florian, Schwab, Albrecht, Wege, Anja Kathrin, Nedvetsky, Pavel, Krahn, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094600/
https://www.ncbi.nlm.nih.gov/pubmed/33941200
http://dx.doi.org/10.1186/s12943-021-01354-2

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