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Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects

Myrf is a pleiotropic membrane-bound transcription factor that plays critical roles in diverse organisms, including in oligodendrocyte differentiation, embryonic development, molting, and synaptic plasticity. Upon autolytic cleavage, the Myrf N-terminal fragment enters the nucleus as a homo-trimer a...

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Detalles Bibliográficos
Autores principales:	Fan, Chuandong, An, Hongjoo, Sharif, Mohamed, Kim, Dongkyeong, Park, Yungki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094900/ https://www.ncbi.nlm.nih.gov/pubmed/33798553 http://dx.doi.org/10.1016/j.jbc.2021.100612

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