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Top1-PARP1 association and beyond: from DNA topology to break repair

Selective trapping of human topoisomerase 1 (Top1) on the DNA (Top1 cleavage complexes; Top1cc) by specific Top1-poisons triggers DNA breaks and cell death. Poly(ADP-ribose) polymerase 1 (PARP1) is an early nick sensor for trapped Top1cc. New mechanistic insights have been developed in recent years...

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Detalles Bibliográficos
Autores principales:	Chowdhuri, Srijita Paul, Das, Benu Brata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Short Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095074/ https://www.ncbi.nlm.nih.gov/pubmed/33981998 http://dx.doi.org/10.1093/narcan/zcab003

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