Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites

Regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial. In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinos...

Descripción completa

Detalles Bibliográficos
Autores principales: Yazici, Aysenur Torun, Gianti, Eleonora, Kasimova, Marina A., Lee, Bo-Hyun, Carnevale, Vincenzo, Rohacs, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095115/
https://www.ncbi.nlm.nih.gov/pubmed/33766560
http://dx.doi.org/10.1016/j.jbc.2021.100573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095115/
https://www.ncbi.nlm.nih.gov/pubmed/33766560
http://dx.doi.org/10.1016/j.jbc.2021.100573

Ejemplares similares