Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes

Inflammasomes are macromolecular complexes involved in the host response to external and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a central role in several human conditions such as autoimmune diseases, type-2 diabetes, and neurodegenerative disorders, indicating in...

Descripción completa

Detalles Bibliográficos
Autores principales: Sebastian-Valverde, Maria, Wu, Henry, Al Rahim, Md, Sanchez, Roberto, Kumar, Kunal, De Vita, Robert J., Pasinetti, Giulio Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095128/
https://www.ncbi.nlm.nih.gov/pubmed/33781745
http://dx.doi.org/10.1016/j.jbc.2021.100597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095128/
https://www.ncbi.nlm.nih.gov/pubmed/33781745
http://dx.doi.org/10.1016/j.jbc.2021.100597

Ejemplares similares