Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice

OBJECTIVE: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to cardiometabolic complications of obesity. Th...

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Detalles Bibliográficos
Autores principales: Bell, Rachel M.B., Villalobos, Elisa, Nixon, Mark, Miguelez-Crespo, Allende, Murphy, Lee, Fawkes, Angie, Coutts, Audrey, Sharp, Matthew G.F., Koerner, Martha V., Allan, Emma, Meijer, Onno C., Houtman, Renè, Odermatt, Alex, Beck, Katharina R., Denham, Scott G., Lee, Patricia, Homer, Natalie Z.M., Walker, Brian R., Morgan, Ruth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095185/
https://www.ncbi.nlm.nih.gov/pubmed/33785425
http://dx.doi.org/10.1016/j.molmet.2021.101225

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