Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies

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Many anti-SARS-CoV-2 neutralizing antibodies target the ACE2-binding site on viral spike receptor-binding domains (RBDs). The most potent antibodies recognize exposed variable epitopes, often rendering them ineffective against other sarbecoviruses and SARS-CoV-2 variants. Class 4 anti-RBD antibodies...

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Detalles Bibliográficos
Autores principales: Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095199/
https://www.ncbi.nlm.nih.gov/pubmed/33948592
http://dx.doi.org/10.1101/2021.04.23.441195
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