Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells

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Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. Here, we evaluate 254 COVID-19 patients longitudinally up to eight months and find durable broad-based immune responses. SARS-CoV-2 spike binding and neutralizing antibodies exhibit a bi-phasic decay with an extended half-l...

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Autores principales: Cohen, Kristen W., Linderman, Susanne L., Moodie, Zoe, Czartoski, Julie, Lai, Lilin, Mantus, Grace, Norwood, Carson, Nyhoff, Lindsay E., Edara, Venkata Viswanadh, Floyd, Katharine, De Rosa, Stephen C., Ahmed, Hasan, Whaley, Rachael, Patel, Shivan N., Prigmore, Brittany, Lemos, Maria P., Davis, Carl W., Furth, Sarah, O’Keefe, James, Gharpure, Mohini P., Gunisetty, Sivaram, Stephens, Kathy A., Antia, Rustom, Zarnitsyna, Veronika I., Stephens, David S., Edupuganti, Srilatha, Rouphael, Nadine, Anderson, Evan J., Mehta, Aneesh K., Wrammert, Jens, Suthar, Mehul S., Ahmed, Rafi, McElrath, M. Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095229/
https://www.ncbi.nlm.nih.gov/pubmed/33948610
http://dx.doi.org/10.1101/2021.04.19.21255739
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