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Lead poisoning from Ayurvedic treatment: a further case
PURPOSE: We report a case of a 30 years old Indian sailor with microcytic anemia (Hb 9.9), persistent abdominal pain, emesis, dark stool, hyperchromic urine, latent jaundice and asthenia. Lead intoxication was confirmed (blood lead value of 102 µg/dL). The patient assumed Ayurvedic medicines in the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885 srl
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095331/ https://www.ncbi.nlm.nih.gov/pubmed/33881010 http://dx.doi.org/10.23749/mdl.v112i2.10576 |
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author | Ciocan, Catalina Mansour, Ihab Beneduce, Alessandro Corgiat Loia, Riccardo Milanesio, Nicolò Declementi, Michael Godono, Alessandro Garzaro, Giacomo Pira, Enrico |
author_facet | Ciocan, Catalina Mansour, Ihab Beneduce, Alessandro Corgiat Loia, Riccardo Milanesio, Nicolò Declementi, Michael Godono, Alessandro Garzaro, Giacomo Pira, Enrico |
author_sort | Ciocan, Catalina |
collection | PubMed |
description | PURPOSE: We report a case of a 30 years old Indian sailor with microcytic anemia (Hb 9.9), persistent abdominal pain, emesis, dark stool, hyperchromic urine, latent jaundice and asthenia. Lead intoxication was confirmed (blood lead value of 102 µg/dL). The patient assumed Ayurvedic medicines in the previous months. Ayurveda is an ancient form of Indian traditional popular medicine aiming to re-establish health and body function through herbal preparations, heavy metals are often added. Our purpose was to treat the patient and to establish the source of poisoning. METHODS: After testing blood and urine lead concentration of other 3 crew members and analyzing over than 150 products used on the ship professional exposure was excluded. We analyzed the two Ayurvedic drugs assumed by the patient with an Inductively Coupled Plasma Mass Spectrometry. The patient underwent three chelation cycles with Calcium Disodium Ethylenediaminetetraacetic acid (EDTA) while monitoring blood and urinary lead levels. RESULTS: The final blood lead level at discharge, after three chelation cycles, was 36.27 µg/dL. One of the two drugs contained extremely high concentrations of lead and mercury. The three different mixtures of this preparation showed lead concentrations of 12,638.54 mg/kg (Sample 2A), 23,043.02 mg/kg (Sample 2B), 21,352.97 mg/kg (Sample 2C); these levels are much higher than the highest values reported in literature for the indian soil (32 mg/kg). CONCLUSIONS: This case and similar cases raise the safety alert on complementary and alternative medicines; Ayurvedic medicine users should be carefully informed about potential risks and signs of poisoning. |
format | Online Article Text |
id | pubmed-8095331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-80953312021-05-05 Lead poisoning from Ayurvedic treatment: a further case Ciocan, Catalina Mansour, Ihab Beneduce, Alessandro Corgiat Loia, Riccardo Milanesio, Nicolò Declementi, Michael Godono, Alessandro Garzaro, Giacomo Pira, Enrico Med Lav Original Article PURPOSE: We report a case of a 30 years old Indian sailor with microcytic anemia (Hb 9.9), persistent abdominal pain, emesis, dark stool, hyperchromic urine, latent jaundice and asthenia. Lead intoxication was confirmed (blood lead value of 102 µg/dL). The patient assumed Ayurvedic medicines in the previous months. Ayurveda is an ancient form of Indian traditional popular medicine aiming to re-establish health and body function through herbal preparations, heavy metals are often added. Our purpose was to treat the patient and to establish the source of poisoning. METHODS: After testing blood and urine lead concentration of other 3 crew members and analyzing over than 150 products used on the ship professional exposure was excluded. We analyzed the two Ayurvedic drugs assumed by the patient with an Inductively Coupled Plasma Mass Spectrometry. The patient underwent three chelation cycles with Calcium Disodium Ethylenediaminetetraacetic acid (EDTA) while monitoring blood and urinary lead levels. RESULTS: The final blood lead level at discharge, after three chelation cycles, was 36.27 µg/dL. One of the two drugs contained extremely high concentrations of lead and mercury. The three different mixtures of this preparation showed lead concentrations of 12,638.54 mg/kg (Sample 2A), 23,043.02 mg/kg (Sample 2B), 21,352.97 mg/kg (Sample 2C); these levels are much higher than the highest values reported in literature for the indian soil (32 mg/kg). CONCLUSIONS: This case and similar cases raise the safety alert on complementary and alternative medicines; Ayurvedic medicine users should be carefully informed about potential risks and signs of poisoning. Mattioli 1885 srl 2021 2021-04-20 /pmc/articles/PMC8095331/ /pubmed/33881010 http://dx.doi.org/10.23749/mdl.v112i2.10576 Text en Copyright: © 2020 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Ciocan, Catalina Mansour, Ihab Beneduce, Alessandro Corgiat Loia, Riccardo Milanesio, Nicolò Declementi, Michael Godono, Alessandro Garzaro, Giacomo Pira, Enrico Lead poisoning from Ayurvedic treatment: a further case |
title | Lead poisoning from Ayurvedic treatment: a further case |
title_full | Lead poisoning from Ayurvedic treatment: a further case |
title_fullStr | Lead poisoning from Ayurvedic treatment: a further case |
title_full_unstemmed | Lead poisoning from Ayurvedic treatment: a further case |
title_short | Lead poisoning from Ayurvedic treatment: a further case |
title_sort | lead poisoning from ayurvedic treatment: a further case |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095331/ https://www.ncbi.nlm.nih.gov/pubmed/33881010 http://dx.doi.org/10.23749/mdl.v112i2.10576 |
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