Increased Mucosal Thrombin is Associated with Crohn’s Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation

BACKGROUND AND AIMS: Thrombin levels in the colon of Crohn’s disease patients have recently been found to be elevated 100-fold compared with healthy controls. Our aim was to determine whether and how dysregulated thrombin activity could contribute to local tissue malfunctions associated with Crohn’s...

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Detalles Bibliográficos
Autores principales: Motta, Jean-Paul, Palese, Simone, Giorgio, Carmine, Chapman, Kevin, Denadai-Souza, Alexandre, Rousset, Perrine, Sagnat, David, Guiraud, Laura, Edir, Anissa, Seguy, Carine, Alric, Laurent, Bonnet, Delphine, Bournet, Barbara, Buscail, Louis, Gilletta, Cyrielle, Buret, Andre G, Wallace, John L, Hollenberg, Morley D, Oswald, Eric, Barocelli, Elisabetta, Le Grand, Sylvie, Le Grand, Bruno, Deraison, Celine, Vergnolle, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095389/
https://www.ncbi.nlm.nih.gov/pubmed/33201214
http://dx.doi.org/10.1093/ecco-jcc/jjaa229

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