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Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians

Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, which reduces ALDH2 enzymatic activity by at least 40% relative to wild type ALDH2. Given...

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Autores principales: Goodnough, Candida L, Gross, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095722/
https://www.ncbi.nlm.nih.gov/pubmed/33954271
http://dx.doi.org/10.4103/cp.cp_17_20
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author Goodnough, Candida L
Gross, Eric R.
author_facet Goodnough, Candida L
Gross, Eric R.
author_sort Goodnough, Candida L
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description Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, which reduces ALDH2 enzymatic activity by at least 40% relative to wild type ALDH2. Given the role of ALDH2 in removing toxic aldehydes from the cell, ALDH2 is intimately involved in the cardioprotective mechanisms of ischemic preconditioning and the pathophysiology of ischemia reperfusion injury. The ALDH2*2 variant is associated with an increased incidence of coronary artery disease, myocardial infarction, and stroke. Furthermore, this variant is associated with insensitivity to nitroglycerin, which is commonly prescribed in patients with cardiovascular disease. In this review, we discuss the genetic susceptibility and pathophysiology associated with the ALDH2*2 variant in regards to cardiovascular disease. We also present the considerations for the management of heart disease and stroke specific to East Asians carrying the ALDH2*2 genetic variant.
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spelling pubmed-80957222021-05-04 Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians Goodnough, Candida L Gross, Eric R. Cardiol Plus Article Heart disease is the leading cause of death in Asian Americans. Importantly, people of East Asian descent are more likely to carry a loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2, which reduces ALDH2 enzymatic activity by at least 40% relative to wild type ALDH2. Given the role of ALDH2 in removing toxic aldehydes from the cell, ALDH2 is intimately involved in the cardioprotective mechanisms of ischemic preconditioning and the pathophysiology of ischemia reperfusion injury. The ALDH2*2 variant is associated with an increased incidence of coronary artery disease, myocardial infarction, and stroke. Furthermore, this variant is associated with insensitivity to nitroglycerin, which is commonly prescribed in patients with cardiovascular disease. In this review, we discuss the genetic susceptibility and pathophysiology associated with the ALDH2*2 variant in regards to cardiovascular disease. We also present the considerations for the management of heart disease and stroke specific to East Asians carrying the ALDH2*2 genetic variant. 2020-09-30 2020 /pmc/articles/PMC8095722/ /pubmed/33954271 http://dx.doi.org/10.4103/cp.cp_17_20 Text en https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-Share A like 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact:WKHLRPMedknow_reprints@wolterskluwer.com
spellingShingle Article
Goodnough, Candida L
Gross, Eric R.
Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians
title Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians
title_full Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians
title_fullStr Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians
title_full_unstemmed Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians
title_short Precision Medicine Considerations for the Management of Heart Disease and Stroke in East Asians
title_sort precision medicine considerations for the management of heart disease and stroke in east asians
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095722/
https://www.ncbi.nlm.nih.gov/pubmed/33954271
http://dx.doi.org/10.4103/cp.cp_17_20
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