Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells

Treatment for the lethal primary adult brain tumor glioblastoma (GBM) includes the chemotherapy temozolomide (TMZ), but TMZ resistance is common and correlates with promoter methylation of the DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). To improve treatment of GBMs, including t...

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Detalles Bibliográficos
Autores principales: Williford, Sarah E., Libby, Catherine J., Ayokanmbi, Adetokunbo, Otamias, Arphaxad, Gordillo, Juan J., Gordon, Emily R., Cooper, Sara J., Redmann, Matthew, Li, Yanjie, Griguer, Corinne, Zhang, Jianhua, Napierala, Marek, Ananthan, Subramaniam, Hjelmeland, Anita B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096095/
https://www.ncbi.nlm.nih.gov/pubmed/33945569
http://dx.doi.org/10.1371/journal.pone.0250649

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