Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein–coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...

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Detalles Bibliográficos
Autores principales: Arveseth, Corvin D., Happ, John T., Hedeen, Danielle S., Zhu, Ju-Fen, Capener, Jacob L., Klatt Shaw, Dana, Deshpande, Ishan, Liang, Jiahao, Xu, Jiewei, Stubben, Sara L., Nelson, Isaac B., Walker, Madison F., Kawakami, Kouki, Inoue, Asuka, Krogan, Nevan J., Grunwald, David J., Hüttenhain, Ruth, Manglik, Aashish, Myers, Benjamin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096101/
https://www.ncbi.nlm.nih.gov/pubmed/33886552
http://dx.doi.org/10.1371/journal.pbio.3001191

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