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Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection

SARS CoV-2, a causative agent of human respiratory tract infection, was first identified in late 2019. It is a newly emerging viral disease with unsatisfactory treatments. The virus is highly contagious and has caused pandemic globally. The number of deaths is increasing exponentially, which is an a...

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Detalles Bibliográficos
Autores principales: Sahu, Utkarsha, Biswas, Debasis, Singh, Anirudh Kumar, Khare, Prashant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096142/
https://www.ncbi.nlm.nih.gov/pubmed/33969150
http://dx.doi.org/10.1007/s13337-021-00687-2
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author Sahu, Utkarsha
Biswas, Debasis
Singh, Anirudh Kumar
Khare, Prashant
author_facet Sahu, Utkarsha
Biswas, Debasis
Singh, Anirudh Kumar
Khare, Prashant
author_sort Sahu, Utkarsha
collection PubMed
description SARS CoV-2, a causative agent of human respiratory tract infection, was first identified in late 2019. It is a newly emerging viral disease with unsatisfactory treatments. The virus is highly contagious and has caused pandemic globally. The number of deaths is increasing exponentially, which is an alarming situation for mankind. The detailed mechanism of the pathogenesis and host immune responses to this virus are not fully known. Here we discuss an overview of SARS CoV-2 pathogenicity, its entry and replication mechanism, and host immune response against this deadly pathogen. Understanding these processes will help to lead the development and identification of drug targets and effective therapies.
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spelling pubmed-80961422021-05-05 Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection Sahu, Utkarsha Biswas, Debasis Singh, Anirudh Kumar Khare, Prashant Virusdisease Review Article SARS CoV-2, a causative agent of human respiratory tract infection, was first identified in late 2019. It is a newly emerging viral disease with unsatisfactory treatments. The virus is highly contagious and has caused pandemic globally. The number of deaths is increasing exponentially, which is an alarming situation for mankind. The detailed mechanism of the pathogenesis and host immune responses to this virus are not fully known. Here we discuss an overview of SARS CoV-2 pathogenicity, its entry and replication mechanism, and host immune response against this deadly pathogen. Understanding these processes will help to lead the development and identification of drug targets and effective therapies. Springer India 2021-05-04 2021-06 /pmc/articles/PMC8096142/ /pubmed/33969150 http://dx.doi.org/10.1007/s13337-021-00687-2 Text en © Indian Virological Society 2021
spellingShingle Review Article
Sahu, Utkarsha
Biswas, Debasis
Singh, Anirudh Kumar
Khare, Prashant
Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection
title Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection
title_full Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection
title_fullStr Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection
title_full_unstemmed Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection
title_short Mechanism involved in the pathogenesis and immune response against SARS-CoV-2 infection
title_sort mechanism involved in the pathogenesis and immune response against sars-cov-2 infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096142/
https://www.ncbi.nlm.nih.gov/pubmed/33969150
http://dx.doi.org/10.1007/s13337-021-00687-2
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