Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis

Although overexpression of EZH2, a catalytic subunit of the polycomb repressive complex 2 (PRC2), is an eminent feature of various cancers, the regulation of its abundance and function remains insufficiently understood. We report here that the PRC2 complex is physically associated with ubiquitin-spe...

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Detalles Bibliográficos
Autores principales: Su, Dongxue, Wang, Wenjuan, Hou, Yongqiang, Wang, Liyong, Yi, Xianfu, Cao, Cheng, Wang, Yuejiao, Gao, Huan, Wang, Yue, Yang, Chao, Liu, Beibei, Chen, Xing, Wu, Xiaodi, Wu, Jiajing, Yan, Dong, Wei, Shuqi, Han, Lulu, Liu, Shumeng, Wang, Qian, Shi, Lei, Shan, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096222/
https://www.ncbi.nlm.nih.gov/pubmed/33849069
http://dx.doi.org/10.1093/nar/gkab209

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