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Rational engineering of a modular bacterial CRISPR–Cas activation platform with expanded target range

CRISPR–Cas activator (CRISPRa) systems that selectively turn on transcription of a target gene are a potentially transformative technology for programming cellular function. While in eukaryotes versatile CRISPRa systems exist, in bacteria these systems suffer from a limited ability to activate diffe...

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Detalles Bibliográficos
Autores principales:	Villegas Kcam, Maria Claudia, Tsong, Annette J, Chappell, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096225/ https://www.ncbi.nlm.nih.gov/pubmed/33823546 http://dx.doi.org/10.1093/nar/gkab211

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