Cargando…

SIRT3 consolidates heterochromatin and counteracts senescence

Sirtuin 3 (SIRT3) is an NAD(+)-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. Here we found that SIRT3 expression was downregu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Diao, Zhiqing, Ji, Qianzhao, Wu, Zeming, Zhang, Weiqi, Cai, Yusheng, Wang, Zehua, Hu, Jianli, Liu, Zunpeng, Wang, Qiaoran, Bi, Shijia, Huang, Daoyuan, Ji, Zhejun, Liu, Guang-Hui, Wang, Si, Song, Moshi, Qu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	NAR Breakthrough Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096253/ https://www.ncbi.nlm.nih.gov/pubmed/33706382 http://dx.doi.org/10.1093/nar/gkab161

Ejemplares similares

Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’
por: Diao, Zhiqing, et al.
Publicado: (2021)

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
por: Hu, Huifang, et al.
Publicado: (2020)

A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies
por: Xu, Jing, et al.
Publicado: (2021)

Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
por: El Kazzi, Priscila, et al.
Publicado: (2022)

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
por: Bi, Shijia, et al.
Publicado: (2020)

Construction of a highly error-prone DNA polymerase for developing organelle mutation systems
por: Ji, Junwei, et al.
Publicado: (2020)

Construction of a cross-species cell landscape at single-cell level
por: Wang, Renying, et al.
Publicado: (2022)

YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency
por: Dong, Xiaotao, et al.
Publicado: (2022)

Onepot-Seq: capturing single-cell transcriptomes simultaneously in a continuous medium via transient localization of mRNA
por: Shin, Dongju, et al.
Publicado: (2022)

Synthetic promoter design in Escherichia coli based on a deep generative network
por: Wang, Ye, et al.
Publicado: (2020)

Prp5−Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription
por: Shao, Wei, et al.
Publicado: (2020)

Cryo-electron microscopy structure and translocation mechanism of the crenarchaeal ribosome
por: Wang, Ying-Hui, et al.
Publicado: (2023)

DeepBIO: an automated and interpretable deep-learning platform for high-throughput biological sequence prediction, functional annotation and visualization analysis
por: Wang, Ruheng, et al.
Publicado: (2023)

Reversible acetylation on Lys501 regulates the activity of RNase II
por: Song, Limin, et al.
Publicado: (2016)

Deficiency of ribosomal proteins reshapes the transcriptional and translational landscape in human cells
por: Luan, Yizhao, et al.
Publicado: (2022)

Automated physics-based design of synthetic riboswitches from diverse RNA aptamers
por: Espah Borujeni, Amin, et al.
Publicado: (2016)

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins
por: Wang, Xi, et al.
Publicado: (2023)

Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break
por: Wang, Pingping, et al.
Publicado: (2017)

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse
por: Depreux, Frederic F., et al.
Publicado: (2016)

GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival
por: Lu, Xiaopeng, et al.
Publicado: (2019)

Biogenesis and growth phase-dependent alteration of 5-methoxycarbonylmethoxyuridine in tRNA anticodons
por: Sakai, Yusuke, et al.
Publicado: (2016)

The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs
por: Yamagishi, Ryota, et al.
Publicado: (2016)

Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea
por: Ishino, Sonoko, et al.
Publicado: (2016)

Methylation of histone H3 lysine 9 occurs during translation
por: Rivera, Carlos, et al.
Publicado: (2015)

Structure of a human translation termination complex
por: Matheisl, Sarah, et al.
Publicado: (2015)

A novel role for poly(C) binding proteins in programmed ribosomal frameshifting
por: Napthine, Sawsan, et al.
Publicado: (2016)

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy
por: Short, Judith M., et al.
Publicado: (2016)

Mitochondrial DNA exhibits resistance to induced point and deletion mutations
por: Valente, William J., et al.
Publicado: (2016)

3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM
por: Chua, Eugene Y.D., et al.
Publicado: (2016)

Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase
por: Gupta, Richa, et al.
Publicado: (2017)

DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels
por: Henning-Knechtel, Anja, et al.
Publicado: (2017)

A single active site in the mariner transposase cleaves DNA strands of opposite polarity
por: Claeys Bouuaert, Corentin, et al.
Publicado: (2017)

The mechanisms of a mammalian splicing enhancer
por: Jobbins, Andrew M, et al.
Publicado: (2018)

Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation
por: Katoh, Takayuki, et al.
Publicado: (2017)

Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences
por: Pressman, Abe, et al.
Publicado: (2017)

Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis
por: Tashiro, Sanki, et al.
Publicado: (2017)

Prespacer processing and specific integration in a Type I-A CRISPR system
por: Rollie, Clare, et al.
Publicado: (2018)

Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease
por: Asano, Kana, et al.
Publicado: (2018)

An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity
por: Brancati, Giovanna, et al.
Publicado: (2018)

Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription
por: Belashov, Ivan A, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1b6usmk4ac5gtv5h25tcoqe064