A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation

The lysine specific demethylase 1 (LSD1) plays a pivotal role in cellular differentiation by regulating the expression of key developmental genes in concert with different coregulatory proteins. This process is impaired in different cancer types and incompletely understood. To comprehensively identi...

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Detalles Bibliográficos
Autores principales: Pinter, Sabine, Knodel, Franziska, Choudalakis, Michel, Schnee, Philipp, Kroll, Carolin, Fuchs, Marina, Broehm, Alexander, Weirich, Sara, Roth, Mareike, Eisler, Stephan A, Zuber, Johannes, Jeltsch, Albert, Rathert, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096265/
https://www.ncbi.nlm.nih.gov/pubmed/33823549
http://dx.doi.org/10.1093/nar/gkab180

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