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Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency

Deficient maturations of mitochondrial transcripts are linked to clinical abnormalities but their pathophysiology remains elusive. Previous investigations showed that pathogenic variants in MTO1 for the biosynthesis of τm(5)U of tRNA(Glu), tRNA(Gln), tRNA(Lys), tRNA(Trp) and tRNA(Leu(UUR)) were asso...

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Detalles Bibliográficos
Autores principales:	Zhang, Qinghai, He, Xiao, Yao, Shihao, Lin, Tianxiang, Zhang, Luwen, Chen, Danni, Chen, Chao, Yang, Qingxian, Li, Feng, Zhu, Yi-Min, Guan, Min-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096277/ https://www.ncbi.nlm.nih.gov/pubmed/33836087 http://dx.doi.org/10.1093/nar/gkab228

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