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Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines
Osteoarthritis (OA) is a leading cause of disability among older adults. Numerous pharmaceutical and nonpharmaceutical interventions have been described. Intra-articular injections are commonly the first line treatment. There are several articles, reporting the outcome of corticosteroids (CS), hyalu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096293/ https://www.ncbi.nlm.nih.gov/pubmed/33959026 http://dx.doi.org/10.3389/fphar.2021.661805 |
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author | Pavone, Vito Vescio, Andrea Turchetta, Matteo Giardina, Serena Maria Chiara Culmone, Annalisa Testa, Gianluca |
author_facet | Pavone, Vito Vescio, Andrea Turchetta, Matteo Giardina, Serena Maria Chiara Culmone, Annalisa Testa, Gianluca |
author_sort | Pavone, Vito |
collection | PubMed |
description | Osteoarthritis (OA) is a leading cause of disability among older adults. Numerous pharmaceutical and nonpharmaceutical interventions have been described. Intra-articular injections are commonly the first line treatment. There are several articles, reporting the outcome of corticosteroids (CS), hyaluronic acid (HA) and platelet rich plasma (PRP). The aim of the study is to highlight the usefulness, indication and efficacy of the intra-articular injection of principal drugs. CSs have been shown to reduce the severity of pain, but care should be taken with repeated injections because of potential harm. HA reported good outcomes both for pain reduction and functional improvement. Different national societies guidelines do not recommend the PRP intra-articular injection in the management of knee OA for lack of evidence. In conclusion, the authors affirm that there is some evidence that intra-articular steroids are efficacious, but their benefit may be relatively short lived (<4 weeks). Most of the positive outcome were limited to the studies or part of the studies that considered the injection of high molecular weight as visco-supplementation, with a course of two to four injections a year. |
format | Online Article Text |
id | pubmed-8096293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80962932021-05-05 Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines Pavone, Vito Vescio, Andrea Turchetta, Matteo Giardina, Serena Maria Chiara Culmone, Annalisa Testa, Gianluca Front Pharmacol Pharmacology Osteoarthritis (OA) is a leading cause of disability among older adults. Numerous pharmaceutical and nonpharmaceutical interventions have been described. Intra-articular injections are commonly the first line treatment. There are several articles, reporting the outcome of corticosteroids (CS), hyaluronic acid (HA) and platelet rich plasma (PRP). The aim of the study is to highlight the usefulness, indication and efficacy of the intra-articular injection of principal drugs. CSs have been shown to reduce the severity of pain, but care should be taken with repeated injections because of potential harm. HA reported good outcomes both for pain reduction and functional improvement. Different national societies guidelines do not recommend the PRP intra-articular injection in the management of knee OA for lack of evidence. In conclusion, the authors affirm that there is some evidence that intra-articular steroids are efficacious, but their benefit may be relatively short lived (<4 weeks). Most of the positive outcome were limited to the studies or part of the studies that considered the injection of high molecular weight as visco-supplementation, with a course of two to four injections a year. Frontiers Media S.A. 2021-04-20 /pmc/articles/PMC8096293/ /pubmed/33959026 http://dx.doi.org/10.3389/fphar.2021.661805 Text en Copyright © 2021 Pavone, Vescio, Turchetta, Giardina, Culmone and Testa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Pavone, Vito Vescio, Andrea Turchetta, Matteo Giardina, Serena Maria Chiara Culmone, Annalisa Testa, Gianluca Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines |
title | Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines |
title_full | Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines |
title_fullStr | Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines |
title_full_unstemmed | Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines |
title_short | Injection-Based Management of Osteoarthritis of the Knee: A Systematic Review of Guidelines |
title_sort | injection-based management of osteoarthritis of the knee: a systematic review of guidelines |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096293/ https://www.ncbi.nlm.nih.gov/pubmed/33959026 http://dx.doi.org/10.3389/fphar.2021.661805 |
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