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OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo

PURPOSE: OSU-03012 is a celecoxib derivative lacking cyclooxygenase-2 inhibitory activity and a potent PDK1 inhibitor which has been shown to inhibit tumor growth in various ways. However, the role of OSU-03012 in endometrial carcinoma (EC) in which the PI3K/Akt signaling pathway highly activated ha...

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Detalles Bibliográficos
Autores principales:	Ding, Leilei, Ren, Chenchen, Yang, Li, Wu, Zimeng, Li, Feiyan, Jiang, Dongyuan, Zhu, Yuanhang, Lu, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096345/ https://www.ncbi.nlm.nih.gov/pubmed/33958857 http://dx.doi.org/10.2147/DDDT.S304128

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