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Sleep Disorders in Mitochondrial Diseases

PURPOSE OF REVIEW: We aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the association with their clinical and molecular characteristics. RECENT FINDINGS: Sleep complaints are prevalent in mitochondrial disorders. Sleep-disordered...

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Autores principales: Brunetti, Valerio, Della Marca, Giacomo, Servidei, Serenella, Primiano, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096743/
https://www.ncbi.nlm.nih.gov/pubmed/33948737
http://dx.doi.org/10.1007/s11910-021-01121-2
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author Brunetti, Valerio
Della Marca, Giacomo
Servidei, Serenella
Primiano, Guido
author_facet Brunetti, Valerio
Della Marca, Giacomo
Servidei, Serenella
Primiano, Guido
author_sort Brunetti, Valerio
collection PubMed
description PURPOSE OF REVIEW: We aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the association with their clinical and molecular characteristics. RECENT FINDINGS: Sleep complaints are prevalent in mitochondrial disorders. Sleep-disordered breathing is the main sleep disorder reported in mitochondrial diseases. OSA and CSA are, respectively, more frequently associated with patients characterized by the prevalent involvement of the skeletal muscle and the predominant involvement of the central nervous system. Other sleep disorders, such as restless legs syndrome, have been rarely described. SUMMARY: Sleep disorders are frequently associated with primary mitochondrial disorders, and the clinical phenotypes affect the type of sleep disturbance associated with the mitochondrial dysfunction. A polysomnographic study should be performed in every subject with this neurogenetic disorder both at diagnosis and during follow-up for the numerous adverse clinical outcomes associated with sleep disorders and the frailty of mitochondrial patients.
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spelling pubmed-80967432021-05-05 Sleep Disorders in Mitochondrial Diseases Brunetti, Valerio Della Marca, Giacomo Servidei, Serenella Primiano, Guido Curr Neurol Neurosci Rep Sleep (M. Thorpy and M. Billiard, Section Editors) PURPOSE OF REVIEW: We aim to summarize the sleep disorders reported in patients affected by primary mitochondrial dysfunctions and describe the association with their clinical and molecular characteristics. RECENT FINDINGS: Sleep complaints are prevalent in mitochondrial disorders. Sleep-disordered breathing is the main sleep disorder reported in mitochondrial diseases. OSA and CSA are, respectively, more frequently associated with patients characterized by the prevalent involvement of the skeletal muscle and the predominant involvement of the central nervous system. Other sleep disorders, such as restless legs syndrome, have been rarely described. SUMMARY: Sleep disorders are frequently associated with primary mitochondrial disorders, and the clinical phenotypes affect the type of sleep disturbance associated with the mitochondrial dysfunction. A polysomnographic study should be performed in every subject with this neurogenetic disorder both at diagnosis and during follow-up for the numerous adverse clinical outcomes associated with sleep disorders and the frailty of mitochondrial patients. Springer US 2021-05-05 2021 /pmc/articles/PMC8096743/ /pubmed/33948737 http://dx.doi.org/10.1007/s11910-021-01121-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Sleep (M. Thorpy and M. Billiard, Section Editors)
Brunetti, Valerio
Della Marca, Giacomo
Servidei, Serenella
Primiano, Guido
Sleep Disorders in Mitochondrial Diseases
title Sleep Disorders in Mitochondrial Diseases
title_full Sleep Disorders in Mitochondrial Diseases
title_fullStr Sleep Disorders in Mitochondrial Diseases
title_full_unstemmed Sleep Disorders in Mitochondrial Diseases
title_short Sleep Disorders in Mitochondrial Diseases
title_sort sleep disorders in mitochondrial diseases
topic Sleep (M. Thorpy and M. Billiard, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096743/
https://www.ncbi.nlm.nih.gov/pubmed/33948737
http://dx.doi.org/10.1007/s11910-021-01121-2
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