Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage

The spread of SARS-CoV-2 is a global concern that has taken a toll on entire human health. Researchers across the globe have been working in devising the strategies to combat this dreadful disease. Studies focused on genetic variability help design effective drugs and vaccines. Considering this, the...

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Detalles Bibliográficos
Autores principales: Gupta, Suruchi, Paul, Prosenjit, Singh, Ravail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096765/
https://www.ncbi.nlm.nih.gov/pubmed/33969236
http://dx.doi.org/10.1016/j.genrep.2021.101185
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author Gupta, Suruchi
Paul, Prosenjit
Singh, Ravail
author_facet Gupta, Suruchi
Paul, Prosenjit
Singh, Ravail
author_sort Gupta, Suruchi
collection PubMed
description The spread of SARS-CoV-2 is a global concern that has taken a toll on entire human health. Researchers across the globe have been working in devising the strategies to combat this dreadful disease. Studies focused on genetic variability help design effective drugs and vaccines. Considering this, the present study entails the information regarding the genome-wide mutations detected in the 108 SARS CoV-2 genomes worldwide. We identified a few hypervariable regions localized in orf1ab, spike, and nucleocapsid gene. These nucleotide polymorphisms demonstrated their effect on both codon usage as well as amino acid usage pattern. Altogether the present study provides valuable information that would be helpful to ongoing research on 2019-nCoV vaccine development.
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spelling pubmed-80967652021-05-05 Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage Gupta, Suruchi Paul, Prosenjit Singh, Ravail Gene Rep Article The spread of SARS-CoV-2 is a global concern that has taken a toll on entire human health. Researchers across the globe have been working in devising the strategies to combat this dreadful disease. Studies focused on genetic variability help design effective drugs and vaccines. Considering this, the present study entails the information regarding the genome-wide mutations detected in the 108 SARS CoV-2 genomes worldwide. We identified a few hypervariable regions localized in orf1ab, spike, and nucleocapsid gene. These nucleotide polymorphisms demonstrated their effect on both codon usage as well as amino acid usage pattern. Altogether the present study provides valuable information that would be helpful to ongoing research on 2019-nCoV vaccine development. Elsevier Inc. 2021-09 2021-05-05 /pmc/articles/PMC8096765/ /pubmed/33969236 http://dx.doi.org/10.1016/j.genrep.2021.101185 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gupta, Suruchi
Paul, Prosenjit
Singh, Ravail
Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage
title Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage
title_full Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage
title_fullStr Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage
title_full_unstemmed Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage
title_short Analysis of single nucleotide polymorphisms between 2019-nCoV genomes and its impact on codon usage
title_sort analysis of single nucleotide polymorphisms between 2019-ncov genomes and its impact on codon usage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096765/
https://www.ncbi.nlm.nih.gov/pubmed/33969236
http://dx.doi.org/10.1016/j.genrep.2021.101185
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AT singhravail analysisofsinglenucleotidepolymorphismsbetween2019ncovgenomesanditsimpactoncodonusage

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