Cargando…

Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial

This study aimed to investigate the role of baseline levels of peripheral inflammation when testing the efficacy of antidepressant augmentation with minocycline in patients with treatment-resistant depression. We conducted a 4-week, placebo-controlled, randomised clinical trial of minocycline (200 m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nettis, Maria Antonietta, Lombardo, Giulia, Hastings, Caitlin, Zajkowska, Zuzanna, Mariani, Nicole, Nikkheslat, Naghmeh, Worrell, Courtney, Enache, Daniela, McLaughlin, Anna, Kose, Melisa, Sforzini, Luca, Bogdanova, Anna, Cleare, Anthony, Young, Allan H., Pariante, Carmine M., Mondelli, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096832/ https://www.ncbi.nlm.nih.gov/pubmed/33504955 http://dx.doi.org/10.1038/s41386-020-00948-6

Ejemplares similares

Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response
por: Lombardo, Giulia, et al.
Publicado: (2022)

The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression
por: Nettis, Maria Antonietta, et al.
Publicado: (2023)

The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels
por: McLaughlin, Anna P., et al.
Publicado: (2022)

Childhood trauma, HPA axis activity and antidepressant response in patients with depression
por: Nikkheslat, Naghmeh, et al.
Publicado: (2020)

Correction: Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study
por: Cattaneo, Annamaria, et al.
Publicado: (2020)

Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study
por: Cattaneo, Annamaria, et al.
Publicado: (2020)

Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study
por: Sforzini, Luca, et al.
Publicado: (2023)

Inflammation in cancer and depression: a starring role for the kynurenine pathway
por: Sforzini, Luca, et al.
Publicado: (2019)

Using quantitative MRI to study brain responses to immune challenge with interferon-α
por: Nettis, Maria Antonietta, et al.
Publicado: (2021)

PET imaging shows no changes in TSPO brain density after IFN-α immune challenge in healthy human volunteers
por: Nettis, M. A., et al.
Publicado: (2020)

Ketamine’s effect on inflammation and kynurenine pathway in depression: A systematic review
por: Kopra, Emma, et al.
Publicado: (2021)

Differential effect of interferon-alpha treatment on AEA and 2-AG levels
por: Zajkowska, Zuzanna, et al.
Publicado: (2020)

The Role of Peripheral Inflammation in Clinical Outcome and Brain Imaging Abnormalities in Psychosis: A Systematic Review
por: Kose, Melisa, et al.
Publicado: (2021)

Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome
por: Russell, Alice, et al.
Publicado: (2019)

Minocycline in Major Depressive Disorder: And overview with considerations on treatment-resistance and comparisons with other psychiatric disorders
por: Nettis, Maria Antonietta
Publicado: (2021)

The role of circulatory systemic environment in predicting interferon-alpha–induced depression: The neurogenic process as a potential mechanism
por: Borsini, Alessandra, et al.
Publicado: (2019)

Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
por: Mondelli, Valeria, et al.
Publicado: (2021)

Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
por: Boorman, Emily, et al.
Publicado: (2015)

Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial
por: Herniman, Sarah E., et al.
Publicado: (2023)

Cause or consequence? Understanding the role of cortisol in the increased inflammation observed in depression
por: Amasi-Hartoonian, Nare, et al.
Publicado: (2022)

What can neuroimmunology teach us about the symptoms of long-COVID?
por: Mondelli, Valeria, et al.
Publicado: (2021)

Transcriptomics in Interferon-α-Treated Patients Identifies Inflammation-, Neuroplasticity- and Oxidative Stress-Related Signatures as Predictors and Correlates of Depression
por: Hepgul, Nilay, et al.
Publicado: (2016)

The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial
por: Deakin, Bill, et al.
Publicado: (2018)

Antidepressant Compounds Can Be Both Pro- and Anti-Inflammatory in Human Hippocampal Cells
por: Horowitz, Mark Abie, et al.
Publicado: (2015)

Targeting inflammation in depression: Ketamine as an anti-inflammatory antidepressant in psychiatric emergency
por: Nikkheslat, Naghmeh
Publicado: (2021)

Genetic Contributions of Inflammation to Depression
por: Barnes, Jacob, et al.
Publicado: (2017)

Peripheral immune markers and antipsychotic non-response in psychosis
por: Enache, Daniela, et al.
Publicado: (2021)

A Modest Increase in (11)C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index
por: Schubert, Julia J., et al.
Publicado: (2021)

Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression
por: Althubaity, Noha, et al.
Publicado: (2021)

The relationship between salivary C-reactive protein and cognitive function in children aged 11–14 years: Does psychopathology have a moderating effect?
por: Cullen, Alexis E., et al.
Publicado: (2017)

Cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD): evidence from a systematic review with meta-analysis
por: Chang, Jane Pei-Chen, et al.
Publicado: (2021)

In(s) and out(s) of adolescent depression – Trajectories of development and recovery
por: Zajkowska, Zuzanna
Publicado: (2021)

Inflammatory Proteins and Clinical Response to Psychological Therapy in Patients with Depression: An Exploratory Study
por: Strawbridge, Rebecca, et al.
Publicado: (2020)

Minocycline-induced hyperpigmentation
por: Fiscus, Valena, et al.
Publicado: (2014)

The Anticancer Potential of Doxycycline and Minocycline—A Comparative Study on Amelanotic Melanoma Cell Lines
por: Rok, Jakub, et al.
Publicado: (2022)

A Systematic Review of Cognitive Function in First-Episode Psychosis, Including a Discussion on Childhood Trauma, Stress, and Inflammation
por: Aas, Monica, et al.
Publicado: (2014)

T14. ASSESSING DIFFERENCES IN INFLAMMATORY MARKERS BETWEEN FIRST EPISODE PSYCHOSIS PATIENTS AND HEALTHY CONTROLS: THE IMPORTANCE OF CONTROLLING FOR CONFOUNDING FACTORS
por: Giordano, Annalisa, et al.
Publicado: (2018)

Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers
por: Mariani, Nicole, et al.
Publicado: (2021)

Modulation of microglial activation by antidepressants
por: Mariani, Nicole, et al.
Publicado: (2022)

From dried bear bile to molecular investigation of differential effects of bile acids in ex vivo and in vitro models of myocardial dysfunction: Relevance for neuroinflammation
por: Huang, Fei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0pol5sukrqc0f31jmrcgvu977f