Flow Cytometry in the Diagnosis of Canine T-Cell Lymphoma

T cell lymphoma (TCL) is a heterogenous group of lymphoid malignancies representing about 30–40% of all canine lymphomas and often harboring a very aggressive behavior. WHO classification identifies the majority of TCLs as peripheral TCL, but other subtypes with peculiar presentation and outcome hav...

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Detalles Bibliográficos
Autores principales: Comazzi, Stefano, Riondato, Fulvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096896/
https://www.ncbi.nlm.nih.gov/pubmed/33969027
http://dx.doi.org/10.3389/fvets.2021.600963
Descripción
Sumario:T cell lymphoma (TCL) is a heterogenous group of lymphoid malignancies representing about 30–40% of all canine lymphomas and often harboring a very aggressive behavior. WHO classification identifies the majority of TCLs as peripheral TCL, but other subtypes with peculiar presentation and outcome have been recognized. This review aims to explore the use of flow cytometry for refining the diagnosis of canine TCL, putting a particular emphasis on the identification of some peculiar immunotypes, such as T zone lymphoma; on the investigation of putative prognostic markers; and on the evaluation of lymphoma stage and of the minimal residual disease.

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