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Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies

Cancer is one of the leading causes of death and a major public health problem all over the world. Immunotherapy is becoming a revolutionary clinical management for various cancer types. Restoration of aberrant immune surveillance on cancers has achieved markable progress in the past years by either...

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Autores principales: Dong, Yan, Wan, Zhuo, Gao, Xiaotong, Yang, Guodong, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097044/
https://www.ncbi.nlm.nih.gov/pubmed/33968014
http://dx.doi.org/10.3389/fimmu.2021.609762
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author Dong, Yan
Wan, Zhuo
Gao, Xiaotong
Yang, Guodong
Liu, Li
author_facet Dong, Yan
Wan, Zhuo
Gao, Xiaotong
Yang, Guodong
Liu, Li
author_sort Dong, Yan
collection PubMed
description Cancer is one of the leading causes of death and a major public health problem all over the world. Immunotherapy is becoming a revolutionary clinical management for various cancer types. Restoration of aberrant immune surveillance on cancers has achieved markable progress in the past years by either in vivo or ex vivo engineering of the immune cells. Here, we summarized the central roles of immune cells in tumor progression and regression, and the existing and emerging strategies for different immune cell-based immunotherapies. In addition, the current challenges and the potential solutions in translating the immunotherapies into the clinic are also discussed.
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spelling pubmed-80970442021-05-06 Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies Dong, Yan Wan, Zhuo Gao, Xiaotong Yang, Guodong Liu, Li Front Immunol Immunology Cancer is one of the leading causes of death and a major public health problem all over the world. Immunotherapy is becoming a revolutionary clinical management for various cancer types. Restoration of aberrant immune surveillance on cancers has achieved markable progress in the past years by either in vivo or ex vivo engineering of the immune cells. Here, we summarized the central roles of immune cells in tumor progression and regression, and the existing and emerging strategies for different immune cell-based immunotherapies. In addition, the current challenges and the potential solutions in translating the immunotherapies into the clinic are also discussed. Frontiers Media S.A. 2021-04-21 /pmc/articles/PMC8097044/ /pubmed/33968014 http://dx.doi.org/10.3389/fimmu.2021.609762 Text en Copyright © 2021 Dong, Wan, Gao, Yang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Dong, Yan
Wan, Zhuo
Gao, Xiaotong
Yang, Guodong
Liu, Li
Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies
title Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies
title_full Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies
title_fullStr Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies
title_full_unstemmed Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies
title_short Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies
title_sort reprogramming immune cells for enhanced cancer immunotherapy: targets and strategies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097044/
https://www.ncbi.nlm.nih.gov/pubmed/33968014
http://dx.doi.org/10.3389/fimmu.2021.609762
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