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Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study

The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host cells by spike (S) protein priming. Single nucleotide polymorphisms (SNPs) in the gene TMPRSS2 have been associated with susc...

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Autores principales: Schönfelder, Kristina, Breuckmann, Katharina, Elsner, Carina, Dittmer, Ulf, Fistera, David, Herbstreit, Frank, Risse, Joachim, Schmidt, Karsten, Sutharsan, Sivagurunathan, Taube, Christian, Jöckel, Karl-Heinz, Siffert, Winfried, Kribben, Andreas, Möhlendick, Birte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097083/
https://www.ncbi.nlm.nih.gov/pubmed/33968142
http://dx.doi.org/10.3389/fgene.2021.667231
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author Schönfelder, Kristina
Breuckmann, Katharina
Elsner, Carina
Dittmer, Ulf
Fistera, David
Herbstreit, Frank
Risse, Joachim
Schmidt, Karsten
Sutharsan, Sivagurunathan
Taube, Christian
Jöckel, Karl-Heinz
Siffert, Winfried
Kribben, Andreas
Möhlendick, Birte
author_facet Schönfelder, Kristina
Breuckmann, Katharina
Elsner, Carina
Dittmer, Ulf
Fistera, David
Herbstreit, Frank
Risse, Joachim
Schmidt, Karsten
Sutharsan, Sivagurunathan
Taube, Christian
Jöckel, Karl-Heinz
Siffert, Winfried
Kribben, Andreas
Möhlendick, Birte
author_sort Schönfelder, Kristina
collection PubMed
description The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host cells by spike (S) protein priming. Single nucleotide polymorphisms (SNPs) in the gene TMPRSS2 have been associated with susceptibility to and severity of H1N1 or H1N9 influenza A virus infections. Functional variants may influence SARS-CoV-2 infection risk and severity of Coronavirus disease 2019 (COVID-19) as well. Therefore, we analyzed the role of SNPs in the gene TMPRSS2 in a German case-control study. We performed genotyping of the SNPs rs2070788, rs383510, and rs12329760 in the gene TMPRSS2 in 239 SARS-CoV-2-positive and 253 SARS-CoV-2-negative patients. We analyzed the association of the SNPs with susceptibility to SARS-CoV-2 infection and severity of COVID-19. SARS-CoV-2-positive and SARS-CoV-2-negative patients did not differ regarding their demographics. The CC genotype of TMPRSS2 rs383510 was associated with a 1.73-fold increased SARS-CoV-2 infection risk, but was not correlated to severity of COVID-19. Neither TMPRSS2 rs2070788 nor rs12329760 polymorphisms were related to SARS-CoV-2 infection risk or severity of COVID-19. In a multivariable analysis (MVA), the rs383510 CC genotype remained an independent predictor for a 2-fold increased SARS-CoV-2 infection risk. In summary, our report appears to be the first showing that the intron variant rs383510 in the gene TMPRSS2 is associated with an increased risk to SARS-CoV-2 infection in a German cohort.
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spelling pubmed-80970832021-05-06 Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study Schönfelder, Kristina Breuckmann, Katharina Elsner, Carina Dittmer, Ulf Fistera, David Herbstreit, Frank Risse, Joachim Schmidt, Karsten Sutharsan, Sivagurunathan Taube, Christian Jöckel, Karl-Heinz Siffert, Winfried Kribben, Andreas Möhlendick, Birte Front Genet Genetics The transmembrane serine protease 2 (TMPRSS2) is the major host protease that enables entry of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) into host cells by spike (S) protein priming. Single nucleotide polymorphisms (SNPs) in the gene TMPRSS2 have been associated with susceptibility to and severity of H1N1 or H1N9 influenza A virus infections. Functional variants may influence SARS-CoV-2 infection risk and severity of Coronavirus disease 2019 (COVID-19) as well. Therefore, we analyzed the role of SNPs in the gene TMPRSS2 in a German case-control study. We performed genotyping of the SNPs rs2070788, rs383510, and rs12329760 in the gene TMPRSS2 in 239 SARS-CoV-2-positive and 253 SARS-CoV-2-negative patients. We analyzed the association of the SNPs with susceptibility to SARS-CoV-2 infection and severity of COVID-19. SARS-CoV-2-positive and SARS-CoV-2-negative patients did not differ regarding their demographics. The CC genotype of TMPRSS2 rs383510 was associated with a 1.73-fold increased SARS-CoV-2 infection risk, but was not correlated to severity of COVID-19. Neither TMPRSS2 rs2070788 nor rs12329760 polymorphisms were related to SARS-CoV-2 infection risk or severity of COVID-19. In a multivariable analysis (MVA), the rs383510 CC genotype remained an independent predictor for a 2-fold increased SARS-CoV-2 infection risk. In summary, our report appears to be the first showing that the intron variant rs383510 in the gene TMPRSS2 is associated with an increased risk to SARS-CoV-2 infection in a German cohort. Frontiers Media S.A. 2021-04-21 /pmc/articles/PMC8097083/ /pubmed/33968142 http://dx.doi.org/10.3389/fgene.2021.667231 Text en Copyright © 2021 Schönfelder, Breuckmann, Elsner, Dittmer, Fistera, Herbstreit, Risse, Schmidt, Sutharsan, Taube, Jöckel, Siffert, Kribben and Möhlendick. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Schönfelder, Kristina
Breuckmann, Katharina
Elsner, Carina
Dittmer, Ulf
Fistera, David
Herbstreit, Frank
Risse, Joachim
Schmidt, Karsten
Sutharsan, Sivagurunathan
Taube, Christian
Jöckel, Karl-Heinz
Siffert, Winfried
Kribben, Andreas
Möhlendick, Birte
Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study
title Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study
title_full Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study
title_fullStr Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study
title_full_unstemmed Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study
title_short Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study
title_sort transmembrane serine protease 2 polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus type 2 infection: a german case-control study
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097083/
https://www.ncbi.nlm.nih.gov/pubmed/33968142
http://dx.doi.org/10.3389/fgene.2021.667231
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