Cargando…

Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory

A growing body of evidence suggests that the interaction between immune and metabolic responses is essential for maintaining tissue and organ homeostasis. These interacting disorders contribute to the development of chronic diseases associated with immune-aging such as diabetes, obesity, atheroscler...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Kang, Ma, Xiumei, Jiang, Zongzhe, Huang, Wei, Gao, Chenlin, Pu, Yueli, Luo, Lifang, Xu, Youhua, Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097165/
https://www.ncbi.nlm.nih.gov/pubmed/33967796
http://dx.doi.org/10.3389/fphar.2021.653940
_version_ 1783688300485148672
author Geng, Kang
Ma, Xiumei
Jiang, Zongzhe
Huang, Wei
Gao, Chenlin
Pu, Yueli
Luo, Lifang
Xu, Youhua
Xu, Yong
author_facet Geng, Kang
Ma, Xiumei
Jiang, Zongzhe
Huang, Wei
Gao, Chenlin
Pu, Yueli
Luo, Lifang
Xu, Youhua
Xu, Yong
author_sort Geng, Kang
collection PubMed
description A growing body of evidence suggests that the interaction between immune and metabolic responses is essential for maintaining tissue and organ homeostasis. These interacting disorders contribute to the development of chronic diseases associated with immune-aging such as diabetes, obesity, atherosclerosis, and nonalcoholic fatty liver disease. In Diabetic wound (DW), innate immune cells respond to the Pathogen-associated molecular patterns (PAMAs) and/or Damage-associated molecular patterns (DAMPs), changes from resting to an active phenotype, and play an important role in the triggering and maintenance of inflammation. Furthermore, the abnormal activation of innate immune pathways secondary to immune-aging also plays a key role in DW healing. Here, we review studies of innate immune cellular molecular events that identify metabolic disorders in the local microenvironment of DW and provide a historical perspective. At the same time, we describe some of the recent progress, such as TLR receptor-mediated intracellular signaling pathways that lead to the activation of NF-κB and the production of various pro-inflammatory mediators, NLRP3 inflammatory via pyroptosis, induction of IL-1β and IL-18, cGAS-STING responds to mitochondrial injury and endoplasmic reticulum stress, links sensing of metabolic stress to activation of pro-inflammatory cascades. Besides, JAK-STAT is also involved in DW healing by mediating the action of various innate immune effectors. Finally, we discuss the great potential of targeting these innate immune pathways and reprogramming innate immune cell phenotypes in DW therapy.
format Online
Article
Text
id pubmed-8097165
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80971652021-05-06 Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory Geng, Kang Ma, Xiumei Jiang, Zongzhe Huang, Wei Gao, Chenlin Pu, Yueli Luo, Lifang Xu, Youhua Xu, Yong Front Pharmacol Pharmacology A growing body of evidence suggests that the interaction between immune and metabolic responses is essential for maintaining tissue and organ homeostasis. These interacting disorders contribute to the development of chronic diseases associated with immune-aging such as diabetes, obesity, atherosclerosis, and nonalcoholic fatty liver disease. In Diabetic wound (DW), innate immune cells respond to the Pathogen-associated molecular patterns (PAMAs) and/or Damage-associated molecular patterns (DAMPs), changes from resting to an active phenotype, and play an important role in the triggering and maintenance of inflammation. Furthermore, the abnormal activation of innate immune pathways secondary to immune-aging also plays a key role in DW healing. Here, we review studies of innate immune cellular molecular events that identify metabolic disorders in the local microenvironment of DW and provide a historical perspective. At the same time, we describe some of the recent progress, such as TLR receptor-mediated intracellular signaling pathways that lead to the activation of NF-κB and the production of various pro-inflammatory mediators, NLRP3 inflammatory via pyroptosis, induction of IL-1β and IL-18, cGAS-STING responds to mitochondrial injury and endoplasmic reticulum stress, links sensing of metabolic stress to activation of pro-inflammatory cascades. Besides, JAK-STAT is also involved in DW healing by mediating the action of various innate immune effectors. Finally, we discuss the great potential of targeting these innate immune pathways and reprogramming innate immune cell phenotypes in DW therapy. Frontiers Media S.A. 2021-04-21 /pmc/articles/PMC8097165/ /pubmed/33967796 http://dx.doi.org/10.3389/fphar.2021.653940 Text en Copyright © 2021 Geng, Ma, Jiang, Huang, Gao, Pu, Luo, Xu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Geng, Kang
Ma, Xiumei
Jiang, Zongzhe
Huang, Wei
Gao, Chenlin
Pu, Yueli
Luo, Lifang
Xu, Youhua
Xu, Yong
Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
title Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
title_full Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
title_fullStr Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
title_full_unstemmed Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
title_short Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
title_sort innate immunity in diabetic wound healing: focus on the mastermind hidden in chronic inflammatory
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097165/
https://www.ncbi.nlm.nih.gov/pubmed/33967796
http://dx.doi.org/10.3389/fphar.2021.653940
work_keys_str_mv AT gengkang innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT maxiumei innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT jiangzongzhe innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT huangwei innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT gaochenlin innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT puyueli innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT luolifang innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT xuyouhua innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory
AT xuyong innateimmunityindiabeticwoundhealingfocusonthemastermindhiddeninchronicinflammatory