Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii

Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii. We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colisti...

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Autores principales: Cheng, Jiaqi, Yan, Jun, Reyna, Zeferino, Slarve, Matt, Lu, Peggy, Spellberg, Brad, Luna, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097462/
https://www.ncbi.nlm.nih.gov/pubmed/33468472
http://dx.doi.org/10.1128/AAC.02204-20
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author Cheng, Jiaqi
Yan, Jun
Reyna, Zeferino
Slarve, Matt
Lu, Peggy
Spellberg, Brad
Luna, Brian
author_facet Cheng, Jiaqi
Yan, Jun
Reyna, Zeferino
Slarve, Matt
Lu, Peggy
Spellberg, Brad
Luna, Brian
author_sort Cheng, Jiaqi
collection PubMed
description Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii. We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colistin significantly suppressed emergence of resistance to rifabutin. Thus, this combination is a promising therapeutic option for highly resistant A. baumannii infections.
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spelling pubmed-80974622021-05-10 Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii Cheng, Jiaqi Yan, Jun Reyna, Zeferino Slarve, Matt Lu, Peggy Spellberg, Brad Luna, Brian Antimicrob Agents Chemother Susceptibility Recently, we reported rifabutin hyperactivity against Acinetobacter baumannii. We sought to characterize potential interactions between rifabutin and colistin, the last-resort drug for carbapenem-resistant infections. Rifabutin and colistin were synergistic in vitro and in vivo, and low-dose colistin significantly suppressed emergence of resistance to rifabutin. Thus, this combination is a promising therapeutic option for highly resistant A. baumannii infections. American Society for Microbiology 2021-03-18 /pmc/articles/PMC8097462/ /pubmed/33468472 http://dx.doi.org/10.1128/AAC.02204-20 Text en Copyright © 2021 Cheng et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Cheng, Jiaqi
Yan, Jun
Reyna, Zeferino
Slarve, Matt
Lu, Peggy
Spellberg, Brad
Luna, Brian
Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
title Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
title_full Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
title_fullStr Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
title_full_unstemmed Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
title_short Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii
title_sort synergistic rifabutin and colistin reduce emergence of resistance when treating acinetobacter baumannii
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097462/
https://www.ncbi.nlm.nih.gov/pubmed/33468472
http://dx.doi.org/10.1128/AAC.02204-20
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