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In Vivo Targeting of Escherichia coli with Vancomycin-Arginine

The ability of vancomycin-arginine (V-r) to extend the spectrum of activity of glycopeptides to Gram-negative bacteria was investigated. Its MIC towards Escherichia coli, including β-lactamase expressing Ambler classes A, B, and D, was 8 to 16 μg/ml. Addition of 8 times the MIC of V-r to E. coli was...

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Detalles Bibliográficos
Autores principales: Neville, Lewis F., Shalit, Itamar, Warn, Peter A., Scheetz, Marc H., Sun, Jiuzhi, Chosy, Madeline B., Wender, Paul A., Cegelski, Lynette, Rendell, Jacob T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097466/
https://www.ncbi.nlm.nih.gov/pubmed/33468474
http://dx.doi.org/10.1128/AAC.02416-20
Descripción
Sumario:The ability of vancomycin-arginine (V-r) to extend the spectrum of activity of glycopeptides to Gram-negative bacteria was investigated. Its MIC towards Escherichia coli, including β-lactamase expressing Ambler classes A, B, and D, was 8 to 16 μg/ml. Addition of 8 times the MIC of V-r to E. coli was acutely bactericidal and associated with a low frequency of resistance (<2.32 × 10(−10)). In vivo, V-r markedly reduced E. coli burden by >7 log(10) CFU/g in a thigh muscle model. These data warrant further development of V-r in combatting E. coli, including resistant forms.