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Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances

Cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) are both greatly important metabolic enzymes in various tissues, including brain. Although expressions of brain CYPs and UGTs and their contributions to drug disposition are much less than liver, both CYPs and UGTs also mediate metaboli...

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Detalles Bibliográficos
Autores principales: Sheng, Yun, Yang, Hanyu, Wu, Tong, Zhu, Liang, Liu, Li, Liu, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097730/
https://www.ncbi.nlm.nih.gov/pubmed/33967789
http://dx.doi.org/10.3389/fphar.2021.650027
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author Sheng, Yun
Yang, Hanyu
Wu, Tong
Zhu, Liang
Liu, Li
Liu, Xiaodong
author_facet Sheng, Yun
Yang, Hanyu
Wu, Tong
Zhu, Liang
Liu, Li
Liu, Xiaodong
author_sort Sheng, Yun
collection PubMed
description Cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) are both greatly important metabolic enzymes in various tissues, including brain. Although expressions of brain CYPs and UGTs and their contributions to drug disposition are much less than liver, both CYPs and UGTs also mediate metabolism of endogenous substances including dopamine and serotonin as well as some drugs such as morphine in brain, demonstrating their important roles in maintenance of brain homeostasis or pharmacological activity of drugs. Some diseases such as epilepsy, Parkinson’s disease and Alzheimer’s disease are often associated with the alterations of CYPs and UGTs in brain, which may be involved in processes of these diseases via disturbing metabolism of endogenous substances or resisting drugs. This article reviewed the alterations of CYPs and UGTs in brain, the effects on endogenous substances and drugs and their clinical significances. Understanding the roles of CYPs and UGTs in brain provides some new strategies for the treatment of central nervous system diseases.
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spelling pubmed-80977302021-05-06 Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances Sheng, Yun Yang, Hanyu Wu, Tong Zhu, Liang Liu, Li Liu, Xiaodong Front Pharmacol Pharmacology Cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) are both greatly important metabolic enzymes in various tissues, including brain. Although expressions of brain CYPs and UGTs and their contributions to drug disposition are much less than liver, both CYPs and UGTs also mediate metabolism of endogenous substances including dopamine and serotonin as well as some drugs such as morphine in brain, demonstrating their important roles in maintenance of brain homeostasis or pharmacological activity of drugs. Some diseases such as epilepsy, Parkinson’s disease and Alzheimer’s disease are often associated with the alterations of CYPs and UGTs in brain, which may be involved in processes of these diseases via disturbing metabolism of endogenous substances or resisting drugs. This article reviewed the alterations of CYPs and UGTs in brain, the effects on endogenous substances and drugs and their clinical significances. Understanding the roles of CYPs and UGTs in brain provides some new strategies for the treatment of central nervous system diseases. Frontiers Media S.A. 2021-04-21 /pmc/articles/PMC8097730/ /pubmed/33967789 http://dx.doi.org/10.3389/fphar.2021.650027 Text en Copyright © 2021 Sheng, Yang, Wu, Zhu, Liu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Sheng, Yun
Yang, Hanyu
Wu, Tong
Zhu, Liang
Liu, Li
Liu, Xiaodong
Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
title Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
title_full Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
title_fullStr Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
title_full_unstemmed Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
title_short Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
title_sort alterations of cytochrome p450s and udp-glucuronosyltransferases in brain under diseases and their clinical significances
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097730/
https://www.ncbi.nlm.nih.gov/pubmed/33967789
http://dx.doi.org/10.3389/fphar.2021.650027
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