Cargando…

Evaluation of cerebrospinal fluid glycoprotein NMB (GPNMB) as a potential biomarker for Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disorder associated with extracellular amyloid-β peptide deposition and progressive neuron loss. Strong evidence supports that neuroinflammatory changes such as the activation of astrocytes and microglia cells are important in the disease p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aichholzer, Freyja, Klafki, Hans-Wolfgang, Ogorek, Isabella, Vogelgsang, Jonathan, Wiltfang, Jens, Scherbaum, Norbert, Weggen, Sascha, Wirths, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097817/ https://www.ncbi.nlm.nih.gov/pubmed/33947460 http://dx.doi.org/10.1186/s13195-021-00828-1

Ejemplares similares

Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia
por: Hüttenrauch, Melanie, et al.
Publicado: (2018)

Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions
por: Vogelgsang, Jonathan, et al.
Publicado: (2018)

RF19 | PSUN351 Glycoprotein-NMB (GPNMB) is Pro-Tumorigenic in Lymphangioleiomyomatosis (LAM)
por: Gibbons, Erin, et al.
Publicado: (2022)

THU551 Glycoprotein-NMB (GPNMB) Is A Potential Lymphangioleiomyomatosis (LAM) Therapeutic Target And Biomarker
por: Gibbons, Erin, et al.
Publicado: (2023)

N-truncated Aβ(4–x) peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models
por: Wirths, Oliver, et al.
Publicado: (2017)

Higher Level of Mismatch in APOE ε4 Carriers for Amyloid-Beta Peptide Alzheimer’s Disease Biomarkers in Cerebrospinal Fluid
por: Vogelgsang, Jonathan, et al.
Publicado: (2019)

SAT-141 Glycoprotein NMB (GPNMB) Is Pro-Tumorigenic in TSC2-Null Cancer Cells and Is a Potential Drug Target and Biomarker for Lymphangioleiomyomatosis (LAM)
por: Gibbons, Erin, et al.
Publicado: (2020)

Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia
por: Spitzer, Philipp, et al.
Publicado: (2011)

Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer (“METRIC”): a randomized multicenter study
por: Vahdat, Linda T., et al.
Publicado: (2021)

A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease
por: Shahpasand-Kroner, Hedieh, et al.
Publicado: (2018)

Role of the kringle‐like domain in glycoprotein NMB for its tumorigenic potential
por: Xie, Rudy, et al.
Publicado: (2019)

Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal squamous cell carcinoma
por: Manevich, Lev, et al.
Publicado: (2022)

Case Report: Alzheimer's Dementia Associated With Cerebrospinal Fluid Neurochondrin Autoantibodies
por: Hansen, Niels, et al.
Publicado: (2022)

Is plasma amyloid-β 1–42/1–40 a better biomarker for Alzheimer’s disease than AβX–42/X–40?
por: Klafki, Hans-Wolfgang, et al.
Publicado: (2022)

Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia
por: Bibl, Mirko, et al.
Publicado: (2012)

N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer’s disease
por: Zampar, S., et al.
Publicado: (2020)

Role of human HGFIN/nmb in breast cancer
por: Metz, Rebecca L, et al.
Publicado: (2007)

Distinct roles of NMB and GRP in itch transmission
por: Wan, Li, et al.
Publicado: (2017)

Matrix Development for the Detection of Phosphorylated Amyloid-β Peptides by MALDI-TOF-MS
por: Liepold, Thomas, et al.
Publicado: (2023)

The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor
por: Neal, Matthew L., et al.
Publicado: (2018)

Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis
por: Yang, Shaoqi, et al.
Publicado: (2023)

The Role of GPNMB in Inflammation
por: Saade, Marina, et al.
Publicado: (2021)

Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
por: Hüttenrauch, M, et al.
Publicado: (2016)

Development and Technical Validation of an Immunoassay for the Detection of APP(669–711) (Aβ(−3–40)) in Biological Samples
por: Klafki, Hans W., et al.
Publicado: (2020)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
por: Bader, Angelika Sabine, et al.
Publicado: (2023)

A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer’s Disease Mouse Model
por: Stazi, Martina, et al.
Publicado: (2023)

Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer
por: Maric, Gordana, et al.
Publicado: (2013)

Total and Phosphorylated Cerebrospinal Fluid Tau in the Differential Diagnosis of Sporadic Creutzfeldt-Jakob Disease and Rapidly Progressive Alzheimer’s Disease
por: Hermann, Peter, et al.
Publicado: (2022)

Blood Platelets in the Progression of Alzheimer’s Disease
por: Gowert, Nina S., et al.
Publicado: (2014)

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models
por: Reinert, Jochim, et al.
Publicado: (2016)

Expression pattern and prognostic impact of glycoprotein non-metastatic B (GPNMB) in triple-negative breast cancer
por: Huang, Yu-Hsiang, et al.
Publicado: (2021)

Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
por: Stazi, Martina, et al.
Publicado: (2021)

Cell-surface GPNMB and induction of stemness
por: Okita, Yukari, et al.
Publicado: (2018)

Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats
por: Huang, Jian-Jun, et al.
Publicado: (2012)

Crystal Structure of Outer Membrane Protein NMB0315 from Neisseria meningitidis
por: Wang, Xiangyu, et al.
Publicado: (2011)

BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk
por: Meng, Qing-Tao, et al.
Publicado: (2021)

Distributions of Aβ42 and Aβ42/40 in the Cerebrospinal Fluid in View of the Probability Theory
por: Lewczuk, Piotr, et al.
Publicado: (2021)

Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
por: Weggen, Sascha, et al.
Publicado: (2012)

Cerebrospinal fluid biomarkers in psychiatric autoimmune encephalitis: a retrospective cohort study
por: Hansen, Niels, et al.
Publicado: (2023)

Cerebrospinal Fluid Homer-3 Autoantibodies in a Patient with Amnestic Mild Cognitive Impairment
por: Hansen, Niels, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_462mahas912rjplo90hsbg7a3r