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The Eating Disorders Genetics Initiative (EDGI): study protocol

BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included f...

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Autores principales: Bulik, Cynthia M., Thornton, Laura M., Parker, Richard, Kennedy, Hannah, Baker, Jessica H., MacDermod, Casey, Guintivano, Jerry, Cleland, Lana, Miller, Allison L., Harper, Lauren, Larsen, Janne T., Yilmaz, Zeynep, Grove, Jakob, Sullivan, Patrick F., Petersen, Liselotte V., Jordan, Jennifer, Kennedy, Martin A., Martin, Nicholas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097919/
https://www.ncbi.nlm.nih.gov/pubmed/33947359
http://dx.doi.org/10.1186/s12888-021-03212-3
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author Bulik, Cynthia M.
Thornton, Laura M.
Parker, Richard
Kennedy, Hannah
Baker, Jessica H.
MacDermod, Casey
Guintivano, Jerry
Cleland, Lana
Miller, Allison L.
Harper, Lauren
Larsen, Janne T.
Yilmaz, Zeynep
Grove, Jakob
Sullivan, Patrick F.
Petersen, Liselotte V.
Jordan, Jennifer
Kennedy, Martin A.
Martin, Nicholas G.
author_facet Bulik, Cynthia M.
Thornton, Laura M.
Parker, Richard
Kennedy, Hannah
Baker, Jessica H.
MacDermod, Casey
Guintivano, Jerry
Cleland, Lana
Miller, Allison L.
Harper, Lauren
Larsen, Janne T.
Yilmaz, Zeynep
Grove, Jakob
Sullivan, Patrick F.
Petersen, Liselotte V.
Jordan, Jennifer
Kennedy, Martin A.
Martin, Nicholas G.
author_sort Bulik, Cynthia M.
collection PubMed
description BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). DISCUSSION: EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver “actionable” findings that can be transformed into clinically meaningful insights. TRIAL REGISTRATION: EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101.
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spelling pubmed-80979192021-05-05 The Eating Disorders Genetics Initiative (EDGI): study protocol Bulik, Cynthia M. Thornton, Laura M. Parker, Richard Kennedy, Hannah Baker, Jessica H. MacDermod, Casey Guintivano, Jerry Cleland, Lana Miller, Allison L. Harper, Lauren Larsen, Janne T. Yilmaz, Zeynep Grove, Jakob Sullivan, Patrick F. Petersen, Liselotte V. Jordan, Jennifer Kennedy, Martin A. Martin, Nicholas G. BMC Psychiatry Study Protocol BACKGROUND: The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder. METHODS: A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). DISCUSSION: EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver “actionable” findings that can be transformed into clinically meaningful insights. TRIAL REGISTRATION: EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101. BioMed Central 2021-05-04 /pmc/articles/PMC8097919/ /pubmed/33947359 http://dx.doi.org/10.1186/s12888-021-03212-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Study Protocol
Bulik, Cynthia M.
Thornton, Laura M.
Parker, Richard
Kennedy, Hannah
Baker, Jessica H.
MacDermod, Casey
Guintivano, Jerry
Cleland, Lana
Miller, Allison L.
Harper, Lauren
Larsen, Janne T.
Yilmaz, Zeynep
Grove, Jakob
Sullivan, Patrick F.
Petersen, Liselotte V.
Jordan, Jennifer
Kennedy, Martin A.
Martin, Nicholas G.
The Eating Disorders Genetics Initiative (EDGI): study protocol
title The Eating Disorders Genetics Initiative (EDGI): study protocol
title_full The Eating Disorders Genetics Initiative (EDGI): study protocol
title_fullStr The Eating Disorders Genetics Initiative (EDGI): study protocol
title_full_unstemmed The Eating Disorders Genetics Initiative (EDGI): study protocol
title_short The Eating Disorders Genetics Initiative (EDGI): study protocol
title_sort eating disorders genetics initiative (edgi): study protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8097919/
https://www.ncbi.nlm.nih.gov/pubmed/33947359
http://dx.doi.org/10.1186/s12888-021-03212-3
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