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Temporal gene regulation by p53 is associated with the rotational setting of its binding sites in nucleosomes
The tumor suppressor protein p53 is a DNA-binding transcription factor (TF) that, once activated, coordinates the expression of thousands of target genes. Increased p53 binding to gene promoters occurs shortly after p53 activation. Intriguingly, gene transcription exhibits differential kinetics with...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098069/ https://www.ncbi.nlm.nih.gov/pubmed/33764853 http://dx.doi.org/10.1080/15384101.2021.1904554 |