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Thrombin Aggravates Hypoxia/Reoxygenation Injury of Cardiomyocytes by Activating an Autophagy Pathway-Mediated by SIRT1

BACKGROUND: Acute myocardial infarction is the leading cause of mortality among adults worldwide. The present study aimed to investigate the role and mechanism of thrombin and SIRT1 in hypoxia/reoxygenation (H/R) injury. MATERIAL/METHODS: H9c2 cardiomyocytes were used to create an H/R model to simul...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaoning, Xu, Yunhe, Li, Lingbo, Lu, Weiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2021
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098101/ https://www.ncbi.nlm.nih.gov/pubmed/33931577 http://dx.doi.org/10.12659/MSM.928480

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