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JAK1 selective inhibitors for the treatment of spondyloarthropathies

As our understanding of the pathogenesis of SpA improves, focus has turned to the role janus kinase (JAK)-mediated signal transduction and inhibiting its actions as a therapeutic mechanism. Small molecule inhibitors of JAK exist, with variable selectivity for the different JAK isoforms. Less selecti...

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Detalles Bibliográficos
Autores principales: White, Jonathan P E, Coates, Laura C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098108/
https://www.ncbi.nlm.nih.gov/pubmed/33950224
http://dx.doi.org/10.1093/rheumatology/keaa815