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A bifunctional iminophosphorane squaramide catalyzed enantioselective synthesis of hydroquinazolines via intramolecular aza-Michael reaction to α,β-unsaturated esters

An efficient synthesis of enantioenriched hydroquinazoline cores via a novel bifunctional iminophosphorane squaramide catalyzed intramolecular aza-Michael reaction of urea-linked α,β-unsaturated esters is described. The methodology exhibits a high degree of functional group tolerance around the form...

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Detalles Bibliográficos
Autores principales:	Su, Guanglong, Thomson, Connor J., Yamazaki, Ken, Rozsar, Daniel, Christensen, Kirsten E., Hamlin, Trevor A., Dixon, Darren J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098679/ https://www.ncbi.nlm.nih.gov/pubmed/33996002 http://dx.doi.org/10.1039/d1sc00856k

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