Cargando…
Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation
Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the molecular mechanism that drives spindle elongation in human cells is unknown. Using combined depletion and...
Autores principales: | Vukušić, Kruno, Ponjavić, Ivana, Buđa, Renata, Risteski, Patrik, Tolić, Iva M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098747/ https://www.ncbi.nlm.nih.gov/pubmed/33910056 http://dx.doi.org/10.1016/j.devcel.2021.04.005 |
Ejemplares similares
-
Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
por: Vukušić, Kruno, et al.
Publicado: (2017) -
PRC1‐labeled microtubule bundles and kinetochore pairs show one‐to‐one association in metaphase
por: Polak, Bruno, et al.
Publicado: (2016) -
Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces
por: Jagrić, Mihaela, et al.
Publicado: (2021) -
Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth
por: Krüger, Lara Katharina, et al.
Publicado: (2021) -
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles
por: Miyamoto, David T., et al.
Publicado: (2004)