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PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization

Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine in a relapsing and remitting manner. In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine mon...

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Detalles Bibliográficos
Autores principales:	Rana, Mohammad Nasiruddin, Lu, Jie, Xue, Enfu, Ruan, Jingjing, Liu, Yuting, Zhang, Lejun, Dhar, Rana, Li, Yajun, Hu, Zhengqiang, Zhou, Jie, Ma, Wangqian, Tang, Huifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098793/ https://www.ncbi.nlm.nih.gov/pubmed/33967779 http://dx.doi.org/10.3389/fphar.2021.643215

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