Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization

Amyloid beta (Aβ) is a major component of amyloid plaques, which are a key pathological hallmark found in the brains of Alzheimer’s disease (AD) patients. We show that statins are effective at reducing Aβ in human neurons from nondemented control subjects, as well as subjects with familial AD and sp...

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Detalles Bibliográficos
Autores principales: Langness, Vanessa F., van der Kant, Rik, Das, Utpal, Wang, Louie, Chaves, Rodrigo dos Santos, Goldstein, Lawrence S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098827/
https://www.ncbi.nlm.nih.gov/pubmed/33296223
http://dx.doi.org/10.1091/mbc.E20-05-0345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098827/
https://www.ncbi.nlm.nih.gov/pubmed/33296223
http://dx.doi.org/10.1091/mbc.E20-05-0345

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